Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 9/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727944 | 0.90 | LRRK2 (0.59) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1728185 | 0.90 | MAPT (0.55) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1726609 | 0.84 | MAPT (0.54) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1727649 | 0.83 | MEN1 (0.60) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1728196 | 0.81 | LMNA (0.50) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1728020 | 0.80 | KMT2A (0.60) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1726674 | 0.77 | NPC1 (0.52) | SMN1; SMN2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL5713530 | 0.76 | MAP3K5 (0.75) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1726841 | 0.76 | PHGDH (0.60) | SMN1; SMN2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1726833 | 0.75 | KDM4A (0.60) | SMN1; SMN2MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |