Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.59 |
| ▸ | DRD3 | P35462 | 4/20 | 0.59 |
| ▸ | HRH1 | P35367 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728674 | 0.88 | ALDH1A1 (0.60) | DRD2DRD3HRH1HRH3HRH2 | |
| SCHEMBL6081563 | 0.87 | LTA4H (0.55) | HRH3LTA4HMCHR1KCNH2MCHR2 | |
| SCHEMBL1728438 | 0.86 | LTA4H (0.56) | HRH1HRH3HRH2LTA4HMCHR1 | |
| SCHEMBL1728604 | 0.84 | DRD3 (0.59) | DRD2DRD3SIGMAR1LTA4HMCHR1 | |
| SCHEMBL1728503 | 0.84 | LTA4H (0.54) | TMEM97SIGMAR1HRH3LTA4HMCHR1 | |
| SCHEMBL1728694 | 0.84 | KDM4E (0.56) | SIGMAR1HRH3LTA4HMCHR1KCNH2 | |
| SCHEMBL1729170 | 0.82 | LTA4H (0.51) | HRH1HRH3HRH2LTA4HMCHR1 | |
| SCHEMBL1728498 | 0.82 | LTA4H (0.51) | HRH1HRH3HRH2LTA4HMCHR1 | |
| SCHEMBL6081977 | 0.81 | LTA4H (0.56) | DRD2DRD3HRH1HTR1AHTR2A | |
| SCHEMBL6081709 | 0.81 | TMEM97 (0.69) | TMEM97SIGMAR1HRH3LTA4HMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |