Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081520 | 0.82 | HTR1A (0.59) | LTA4HPLA2G2AHTR1AGPR18KCNH2 | |
| SCHEMBL1728610 | 0.82 | KCNH2 (0.57) | LTA4HKCNH2MCHR1 | |
| SCHEMBL6081348 | 0.80 | LTA4H (0.51) | LTA4HKCNH2MCHR1SMN1; SMN2 | |
| SCHEMBL1728135 | 0.80 | LTA4H (0.51) | LTA4HKCNH2MCHR1 | |
| SCHEMBL1728641 | 0.78 | GNRHR (0.48) | LTA4HNPSR1KCNH2MCHR1 | |
| SCHEMBL1728669 | 0.77 | LTA4H (0.68) | LTA4HKCNH2MCHR1SMN1; SMN2 | |
| SCHEMBL1728748 | 0.77 | MCHR1 (0.66) | LTA4HBCHEKCNH2MCHR1KMT2A | |
| SCHEMBL1728580 | 0.73 | LTA4H (0.51) | LTA4HKCNH2MCHR1SMN1; SMN2KMT2A | |
| SCHEMBL1729935 | 0.73 | MCHR1 (0.45) | LTA4HADRA1AADRA1BKCNH2MCHR1 | |
| SCHEMBL30896267 | 0.72 | HTR2A (0.81) | HTR1AHTR2AHTR2CHTR2BBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |