Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.48 |
| ▸ | HTR7 | P34969 | 13/20 | 0.48 |
| ▸ | DRD2 | P14416 | 10/20 | 0.48 |
| ▸ | HTR6 | P50406 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1730296 | 0.97 | HTR1A (0.46) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4188853 | 0.91 | KDM4E (0.47) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL1728664 | 0.88 | KDM4E (0.51) | HTR1AHTR7DRD2HTR6LMNA | |
| SCHEMBL4168448 | 0.88 | HRH3 (0.47) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4179707 | 0.88 | DRD2 (0.53) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL1730433 | 0.87 | HTR1A (0.47) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4179288 | 0.85 | USP2 (0.48) | HTR1ADRD2HTR2AMAPK14LMNA | |
| SCHEMBL1728667 | 0.85 | HTR1A (0.45) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4178438 | 0.84 | USP2 (0.53) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4177226 | 0.79 | LTA4H (0.58) | HTR1AHTR7DRD2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | M'S SCIENCE CORPORATION (JP) | 2009-09-03 | — | — | US | claimed |
| EP-1988902-B1 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-20090221607-A1 | Piperazine Derivatives | M'S SCIENCE CORPORATION (JP) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | SIGMAR1, OPRL1, OPRK1 | HTR1A 25/4885HTR7 170/4885DRD2 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.