Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 7/20 | 0.45 |
| ▸ | HTR7 | P34969 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188853 | 0.97 | KDM4E (0.47) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1730296 | 0.92 | HTR1A (0.46) | KDM4ENFE2L2HTR1AHTR7LMNA | |
| SCHEMBL1728660 | 0.88 | HTR1A (0.48) | MEN1KMT2AHTR1AHTR7LMNA | |
| SCHEMBL4178438 | 0.88 | USP2 (0.53) | MEN1ALDH1A1KMT2AHTR1AHTR7 | |
| SCHEMBL4182952 | 0.88 | KDM4E (0.54) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1728654 | 0.88 | KDM4E (0.49) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4179707 | 0.84 | DRD2 (0.53) | MEN1ALDH1A1KMT2AHTR1AHTR7 | |
| SCHEMBL4174772 | 0.84 | KDM4E (0.50) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4174270 | 0.84 | HTR1A (0.50) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1728667 | 0.80 | HTR1A (0.45) | NFE2L2HTR1AHTR7DRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | M'S SCIENCE CORPORATION (JP) | 2009-09-03 | — | — | US | claimed |
| EP-1988902-B1 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | SIGMAR1, OPRL1, OPRK1 | KDM4E 4592/4885MEN1 3674/4885ALDH1A1 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.