Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174772 | 0.96 | KDM4E (0.50) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4179288 | 0.89 | USP2 (0.48) | MEN1ALDH1A1KMT2AHTR1ADRD2 | |
| SCHEMBL4185461 | 0.88 | USP2 (0.60) | MEN1ALDH1A1KMT2AHTR1ADRD2 | |
| SCHEMBL1728664 | 0.88 | KDM4E (0.51) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4184121 | 0.87 | KDM4E (0.52) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4168448 | 0.85 | HRH3 (0.47) | ALDH1A1HTR1ADRD2HTR2AHRH3 | |
| SCHEMBL4184854 | 0.84 | LTA4H (0.58) | MEN1ALDH1A1KMT2AHTR1ADRD2 | |
| SCHEMBL4188853 | 0.84 | KDM4E (0.47) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1730238 | 0.83 | L3MBTL1 (0.52) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4183852 | 0.80 | DRD2 (0.60) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | M'S SCIENCE CORPORATION (JP) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | SIGMAR1, OPRL1, OPRK1 | KDM4E 4592/4885MEN1 3674/4885ALDH1A1 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.