Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921941 | 0.86 | TSHR (0.42) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL5364252 | 0.79 | TSHR (0.37) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL1138627 | 0.78 | TSHR (0.45) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL11581248 | 0.78 | TSHR (0.38) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL6576220 | 0.78 | TSHR (0.39) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL11581239 | 0.77 | TSHR (0.40) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL9321436 | 0.76 | THRB (0.46) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL10697749 | 0.76 | TSHR (0.50) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL5666395 | 0.76 | TSHR (0.43) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 | |
| Tromethamine SCHEMBL7200431 | 0.75 | ALDH1A1 (0.62) | ALDH1A1TP53CYP3A4MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112639027-B | Pigment dispersion, and resist composition and ink composition for color filter using the same | 佳能株式会社 | 2022-09-23 | — | — | CN | disclosed |
| CN-107109083-B | Radiation curable compositions comprising hydrophilic nanoparticles | 巴斯夫涂料有限公司 | 2021-01-08 | — | — | CN | disclosed |
| CN-105223775-B | Curable composition, method for producing cured film, touch panel, and display device | 富士胶片株式会社 | 2020-03-13 | — | — | CN | disclosed |
| CN-105278246-B | Curable composition, method for producing cured film, touch panel, and display device | 富士胶片株式会社 | 2020-03-13 | — | — | CN | disclosed |
| EP-1142707-B2 | Heat-sensitive lithographic printing plate precursor | FUJIFILM CORP (JP) | 2011-11-30 | — | — | EP | disclosed |
| US-7118848-B2 | Hydrophilic film formed on a metallic base with a roughened surface, and heat conductivity of .05-.5 W/(m middle-dot K) in the direction of its thickness | FUJI PHOTO FILM CO., LTD. (JP) | 2006-10-10 | — | — | US | disclosed |
| EP-1247644-B1 | Support for lithographic printing plate and original forme for lithographic printing plate | FUJI PHOTO FILM CO LTD (JP) | 2006-05-31 | — | — | EP | disclosed |
| EP-1142707-B1 | Heat-sensitive lithographic printing plate precursor | FUJI PHOTO FILM CO LTD (JP) | 2006-05-24 | — | — | EP | disclosed |
| US-20030031860-A1 | Hydrophilic film formed on a metallic base with a roughened surface, and heat conductivity of .05-.5 W/(m middle-dot K) in the direction of its thickness | FUJI PHOTO FILM CO., LTD. | 2003-02-13 | — | — | US | disclosed |
| EP-1247644-A2 | Support for lithographic printing plate and original forme for lithographic printing plate | FUJI PHOTO FILM CO., LTD. (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-20020033108-A1 | Heat-sensitive lithographic printing plate precursor | FUJIFILM CORPORATION (JP) | 2002-03-21 | — | — | US | disclosed |
| EP-1142707-A1 | Heat-sensitive lithographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |
| EP-1116580-A2 | Lithographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2001-07-18 | — | — | EP | disclosed |