Sugi Predict

Sugi Predict / Compounds / SCHEMBL17308310

SCHEMBL17308310

SCHEMBL17308310

CCc1ccnc(OC2CCN(S(C)(=O)=O)CC2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CACNB4 O00305 2/20 0.48
▸ CACNA1A O00555 2/20 0.48
▸ CACNA1G O43497 2/20 0.48
▸ CACNG3 O60359 2/20 0.48
▸ CACNA1F O60840 2/20 0.48
▸ CACNA1H O95180 2/20 0.48
▸ CACNB3 P54284 2/20 0.48
▸ CACNA2D1 P54289 2/20 0.48
▸ CACNG7 P62955 2/20 0.48
▸ CACNA1B Q00975 2/20 0.48
▸ CACNA1D Q01668 2/20 0.48
▸ CACNB1 Q02641 2/20 0.48
▸ CACNG1 Q06432 2/20 0.48
▸ CACNB2 Q08289 2/20 0.48
▸ CACNA1S Q13698 2/20 0.48
▸ CACNA1C Q13936 2/20 0.48
▸ CACNA1E Q15878 2/20 0.48
▸ CACNA2D4 Q7Z3S7 2/20 0.48
▸ CACNA2D3 Q8IZS8 2/20 0.48
▸ CACNG8 Q8WXS5 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15830030 0.83 NAAA (0.48) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL17308301 0.83 LOX (0.52) LOXLOXL2TDO2HCRTR1HCRTR2
SCHEMBL20890609 0.82 LOXL2 (0.60) LOXLOXL2HCRTR1HCRTR2
SCHEMBL21297230 0.80 PRMT5 (0.49) LOXLOXL2HCRTR1HCRTR2
SCHEMBL16217407 0.80 NAAA (0.45) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL19633442 0.80 NAAA (0.45) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL17308336 0.80 LOX (0.66) LOXLOXL2HCRTR1HCRTR2
SCHEMBL17303522 0.79 GPR119 (0.47) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL20252778 0.78 CACNB4 (0.43) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL19633597 0.77 GPR119 (0.47) CACNB4CACNA1ACACNA1GCACNG3CACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10980794-B2 PRMT5 inhibitors and uses thereof Epizyme, Inc. (US) 2021-04-20 — — US disclosed
US-10391089-B2 PRMT5 inhibitors and uses therof Epizyme, Inc. (US) 2019-08-27 — — US disclosed
US-10307413-B2 Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof Epizyme, Inc. (US) 2019-06-04 — — US disclosed
US-20150344434-A1 TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2015-12-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10391089-B2 PRMT5 inhibitors and uses therof PRMT5, PRMT1, PRMT6 CACNB4 4594/4885CACNA1A 4406/4885CACNA1G 4743/4885
US-10307413-B2 Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof PRMT5, PRMT1, PRMT3 CACNB4 4199/4885CACNA1A 3247/4885CACNA1G 4244/4885
US-10980794-B2 PRMT5 inhibitors and uses thereof PRMT5, PRMT1, PRMT6 CACNB4 4513/4885CACNA1A 3951/4885CACNA1G 4577/4885
US-20150344434-A1 TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT3 CACNB4 4219/4885CACNA1A 3294/4885CACNA1G 4274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.