Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435720 | 0.74 | PMP22 (0.34) | LMNAHPGDHIF1AHSD17B10PMP22 | |
| SCHEMBL8089924 | 0.67 | KLF10 (0.34) | LMNAHIF1APMP22 | |
| Ammonia Solution, Strong SCHEMBL11054508 | 0.63 | CA5A (0.42) | HSD17B10CA5A | |
| SCHEMBL30254390 | 0.62 | PMP22 (0.40) | LMNAHPGDHIF1AHSD17B10PMP22 | |
| Sulfuric Acid SCHEMBL2524101 | 0.61 | PMP22 (0.50) | LMNAHPGDHIF1AHSD17B10PMP22 | |
| SCHEMBL28317323 | 0.60 | KLF10 (0.35) | HIF1A | |
| SCHEMBL9770203 | 0.60 | ALDH1A1 (0.48) | LMNAHPGDHIF1AHSD17B10CA5A | |
| SCHEMBL22717116 | 0.60 | TRPA1 (0.50) | CA5A | |
| SCHEMBL9148351 | 0.60 | CISD1 (0.43) | LMNAHPGDHIF1AHSD17B10CA5A | |
| SCHEMBL31578822 | 0.59 | SLC22A6 (0.38) | CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10724092-B2 | Methods for characterizing alternatively or aberrantly spliced mRNA isoforms | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2020-07-28 | — | — | US | disclosed |
| EP-3155128-B1 | METHODS FOR CHARACTERIZING ALTERNATIVELY OR ABERRANTLY SPLICED MRNA ISOFORMS | UNIV ERASMUS MED CT ROTTERDAM (NL) | 2019-05-15 | — | — | EP | disclosed |
| US-20170306399-A1 | METHODS FOR CHARACTERIZING ALTERNATIVELY OR ABERRANTLY SPLICED MRNA ISOFORMS | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2017-10-26 | — | — | US | disclosed |
| EP-3155128-A2 | METHODS FOR CHARACTERIZING ALTERNATIVELY OR ABERRANTLY SPLICED MRNA ISOFORMS | Erasmus University Medical Center Rotterdam (NL) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015190921-A2 | METHODS FOR CHARACTERIZING ALTERNATIVELY OR ABERRANTLY SPLICED MRNA ISOFORMS | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2015-12-17 | — | — | WO | disclosed |