Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | RAPGEF4 | Q8WZA2 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278475 | 0.89 | ALDH1A1 (0.72) | ALDH1A1LMNARAPGEF4HPGDCXCR2 | |
| SCHEMBL5134264 | 0.82 | RAPGEF4 (0.68) | ALDH1A1RAPGEF4HPGDMAPTTDP1 | |
| SCHEMBL1921964 | 0.82 | ALDH1A1 (0.64) | ALDH1A1LMNARAPGEF4HPGDCXCR2 | |
| SCHEMBL4130947 | 0.81 | RAPGEF4 (0.73) | RAPGEF4 | |
| SCHEMBL24318169 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNARAPGEF4TSHRCYP1A2 | |
| SCHEMBL8014673 | 0.79 | ALDH1A1 (0.61) | ALDH1A1RAPGEF4TSHRCYP3A4HPGD | |
| SCHEMBL22202518 | 0.77 | ALDH1A1 (0.58) | ALDH1A1RAPGEF4TSHRHPGDTDP1 | |
| SCHEMBL15871975 | 0.77 | MAPT (0.46) | ALDH1A1LMNATSHRCYP1A2CYP3A4 | |
| SCHEMBL24248250 | 0.76 | ALDH1A1 (0.49) | ALDH1A1LMNARAPGEF4TSHRMAPT | |
| SCHEMBL2927525 | 0.75 | ALDH1A1 (0.54) | ALDH1A1LMNARAPGEF4TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572348-B2 | Syntheses of N-heterocyclic carbenes and intermediates therefor | UMICORE AG & CO. KG (DE) | 2023-02-07 | — | — | US | disclosed |
| US-20210317088-A9 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UMICORE AG & CO. KG (DE) | 2021-10-14 | — | — | US | disclosed |
| US-20200354323-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UMICORE AG & CO. KG (DE) | 2020-11-12 | — | — | US | disclosed |
| US-10759763-B2 | Syntheses of N-heterocyclic carbenes and intermediates therefor | UMICORE AG & CO. KG (DE) | 2020-09-01 | — | — | US | disclosed |
| US-20180186754-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UMICORE AG & CO. KG (DE) | 2018-07-05 | — | — | US | disclosed |
| US-9890125-B2 | Syntheses of N-heterocyclic carbenes and intermediates therefor | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2018-02-13 | — | — | US | disclosed |
| US-20170152231-A9 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UMICORE AG & CO. KG (DE) | 2017-06-01 | — | — | US | disclosed |
| US-20150361049-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | UNIV ST ANDREWS (GB) | 2015-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759763-B2 | Syntheses of N-heterocyclic carbenes and intermediates therefor | GRHPR, DDC, NDC1 | ALDH1A1 726/4885LMNA 3246/4885RAPGEF4 1736/4885 |
| US-11572348-B2 | Syntheses of N-heterocyclic carbenes and intermediates therefor | GRHPR, DDC, NDC1 | ALDH1A1 726/4885LMNA 3246/4885RAPGEF4 1736/4885 |
| US-20170152231-A9 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, WEE2 | ALDH1A1 748/4885LMNA 3135/4885RAPGEF4 1722/4885 |
| US-20180186754-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, NDC1 | ALDH1A1 726/4885LMNA 3246/4885RAPGEF4 1736/4885 |
| US-20210317088-A9 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, NDC1 | ALDH1A1 726/4885LMNA 3246/4885RAPGEF4 1736/4885 |
| US-20200354323-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, NDC1 | ALDH1A1 726/4885LMNA 3246/4885RAPGEF4 1736/4885 |
| US-20150361049-A1 | SYNTHESES OF N-HETEROCYCLIC CARBENES AND INTERMEDIATES THEREFOR | GRHPR, DDC, WEE2 | ALDH1A1 748/4885LMNA 3135/4885RAPGEF4 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.