SCHEMBL5134264

SCHEMBL5134264

Cc1ccc(Nc2c(C)cccc2C)cc1

nearest known ligand 0.68

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 12/20 0.68
ALDH1A1 P00352 1/20 0.64
HPGD P15428 1/20 0.56
KDM1A O60341 1/20 0.50
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
GAA P10253 2/20 0.47
G6PD P11413 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MAPT P10636 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
CXCR2 P25025 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4278475 0.93 ALDH1A1 (0.72) RAPGEF4ALDH1A1HPGDCXCR2
SCHEMBL1921964 0.86 ALDH1A1 (0.64) RAPGEF4ALDH1A1HPGDCXCR2
SCHEMBL1032993 0.86 RAPGEF4 (0.52) RAPGEF4ALDH1A1HPGDKDM1AMEN1
SCHEMBL24318169 0.84 ALDH1A1 (0.62) RAPGEF4ALDH1A1HPGDKDM1AMEN1
SCHEMBL8014673 0.83 ALDH1A1 (0.61) RAPGEF4ALDH1A1HPGDKDM1AMEN1
SCHEMBL11219354 0.82 ALDH1A1 (0.61) RAPGEF4ALDH1A1HPGDKDM1AMEN1
SCHEMBL17344732 0.82 ALDH1A1 (0.60) RAPGEF4ALDH1A1HPGDMAPTTDP1
SCHEMBL15188815 0.81 RAPGEF4 (1.00) RAPGEF4
SCHEMBL22202518 0.80 ALDH1A1 (0.58) RAPGEF4ALDH1A1HPGDKDM1AL3MBTL1
SCHEMBL19087412 0.79 RAPGEF4 (0.71) RAPGEF4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111303325-B Efficient controllable preparation method of polyisoprene 中国科学院青岛生物能源与过程研究所 2022-07-05 CN disclosed
CN-111303325-A Efficient controllable preparation method of polyisoprene 中国科学院青岛生物能源与过程研究所 2020-06-19 CN disclosed
WO-2018128470-A1 ORGANIC ELECTROLUMINESCENT ELEMENT 머티어리얼사이언스 주식회사 2018-07-12 WO disclosed
US-7541462-B2 Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2009-06-02 US disclosed
US-7541462-B2 Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2009-06-02 US disclosed
US-20080139806-A1 TRIAMINOPHOSPHINE LIGANDS FOR CARBON-NITROGEN AND CARBON-CARBON BOND FORMATION IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.. 2008-06-12 US disclosed
US-20080139806-A1 TRIAMINOPHOSPHINE LIGANDS FOR CARBON-NITROGEN AND CARBON-CARBON BOND FORMATION IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.. 2008-06-12 US disclosed
US-7385058-B1 Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2008-06-10 US disclosed
US-7385058-B1 Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2008-06-10 US disclosed
EP-1885669-A1 NUCLEOPHILIC HETEROCYCLIC CARBENE DERIVATIVES OF PD(ACAC)2 FOR CROSS-COUPLING REACTIONS Promerus LLC (US) 2008-02-13 EP disclosed
WO-2006128097-A1 NUCLEOPHILIC HETEROCYCLIC CARBENE DERIVATIVES OF PD(ACAC)2 FOR CROSS-COUPLING REACTIONS PROMERUS LLC (US) 2006-11-30 WO disclosed
EP-0276980-B1 CHROMOGENIC FLUORAN COMPOUNDS ESCO Company Limited Partnership (US) 1992-09-23 EP disclosed
EP-0276980-A2 Chromogenic fluoran compounds ESCO Company Limited Partnership (US) 1988-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080139806-A1 TRIAMINOPHOSPHINE LIGANDS FOR CARBON-NITROGEN AND CARBON-CARBON BOND FORMATION ABL1, AOC1, NPPA RAPGEF4 1735/4885ALDH1A1 3126/4885HPGD 2364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.