SCHEMBL1736

SCHEMBL1736

Cc1noc(-c2ccc(Br)cc2)c1/C(=C\CCO)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.35
TRPA1 O75762 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.33
TBXAS1 P24557 2/20 0.33
LMNA P02545 2/20 0.33
RAB9A P51151 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ALDH1A1 P00352 3/20 0.33
MAPT P10636 2/20 0.33
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
ALOX15 P16050 1/20 0.32
NFKB1 P19838 1/20 0.32
CYP2C19 P33261 1/20 0.32
HIF1A Q16665 1/20 0.32
ADRA2A P08913 1/20 0.32
DRD2 P14416 1/20 0.32
ADRA2B P18089 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7197 0.93 TBXAS1 (0.39) NR1H4TRPA1SMN1; SMN2TBXAS1ALDH1A1
SCHEMBL4758 0.92 IP6K1 (0.40) NR1H4TRPA1SMN1; SMN2TBXAS1LMNA
SCHEMBL3368 0.91 IP6K1 (0.39) TRPA1SMN1; SMN2HPGDMEN1KMT2A
SCHEMBL1633 0.81 NR1H4 (0.33) NR1H4TRPA1SMN1; SMN2ALDH1A1MAPT
SCHEMBL7735 0.78 MEN1 (0.34) RAB9AMAPTMEN1KMT2A
SCHEMBL8250811 0.72 PTPN1 (0.36) NR1H4SMN1; SMN2RAB9AALDH1A1MAPT
SCHEMBL1563 0.71 PTPN1 (0.47) SMN1; SMN2RAB9AALDH1A1MAPTPTGS1
SCHEMBL1294 0.71 MEN1 (0.34) SMN1; SMN2ALDH1A1MAPTCYP1A2CYP2C9
SCHEMBL2110 0.70 TDP1 (0.37) SMN1; SMN2LMNARAB9AALDH1A1MAPT
SCHEMBL6560 0.68 MAPT (0.50) TRPA1SMN1; SMN2LMNARAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483253-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041729-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed