Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7197 | 0.84 | TBXAS1 (0.39) | MAPT | |
| SCHEMBL1736 | 0.78 | NR1H4 (0.35) | MEN1KMT2AMAPTRAB9A | |
| SCHEMBL4758 | 0.75 | IP6K1 (0.40) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3368 | 0.74 | IP6K1 (0.39) | MEN1KMT2ABACE1 | |
| SCHEMBL7129 | 0.68 | BRD4 (0.36) | MEN1KMT2ANPC1MAPTPOLB | |
| SCHEMBL6617 | 0.66 | HDAC1 (0.39) | MEN1KMT2A | |
| SCHEMBL1294 | 0.66 | MEN1 (0.34) | MEN1KMT2ANPC1MAPTNPSR1 | |
| SCHEMBL1784 | 0.65 | ALDH1A1 (0.40) | MEN1KMT2ABACE1NPC1MAPT | |
| SCHEMBL1633 | 0.65 | NR1H4 (0.33) | NPC1MAPTNPSR1POLB | |
| SCHEMBL8250811 | 0.64 | PTPN1 (0.36) | MEN1KMT2ANPC1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |