Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27628189 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Fumaric Acid SCHEMBL27628190 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Fumaric Acid SCHEMBL1736262 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL27712629 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL28157708 | 0.97 | TSHR (0.65) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL28157707 | 0.97 | TSHR (0.65) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Fumaric Acid SCHEMBL8986950 | 0.94 | TSHR (0.61) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL11169845 | 0.92 | TSHR (0.58) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Acrylic Acid SCHEMBL27727809 | 0.88 | LMNA (0.56) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Acrylic Acid SCHEMBL7140121 | 0.87 | ALDH1A1 (0.79) | TSHRALDH1A1FGFR4TP53EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118949667-B | Efficient composite desulfurizing agent and preparation method thereof | 明硕环境科技集团股份有限公司 | 2025-01-14 | — | — | CN | claimed |
| CN-115894965-B | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2024-12-10 | — | — | CN | claimed |
| CN-118949667-A | Efficient composite desulfurizing agent and preparation method thereof | 明硕环境科技集团股份有限公司 | 2024-11-15 | — | — | CN | claimed |
| CN-115716724-B | Concrete hydration synergist and preparation method thereof | 云南森博混凝土外加剂有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-115894965-A | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115716724-A | Concrete hydration synergist and preparation method thereof | 云南森博混凝土外加剂有限公司 | 2023-02-28 | — | — | CN | claimed |
| WO-2022100641-A1 | PHARMACEUTICAL COMPOSITION CONTAINING EGFR INHIBITOR, AND PREPARATION METHOD THEREFOR | 上海海雁医药科技有限公司 | 2022-05-19 | — | — | WO | claimed |
| CN-103086483-B | The method of purifying waste water and comprise the oil production technology of the method | GENERAL ELECTRIC COMPANY (US) | 2015-09-30 | — | — | CN | claimed |
| CN-103086483-A | Water purification method and oil extraction process comprising water purification method | GEN ELECTRIC | 2013-05-08 | — | — | CN | claimed |
| CN-1989075-B | Cerium oxide powder and process for producing the same | LG CHEMICAL LTD | 2010-05-12 | — | — | CN | claimed |
| CN-1989075-A | Cerium oxide powder and process for producing the same | LG CHEMICAL LTD (KR) | 2007-06-27 | — | — | CN | claimed |
| WO-2005030652-A1 | METHODS FOR THE PURIFICATION OF CONTAMINATED WATERS | POLYMER VENTURES, INC. (US) | 2005-04-07 | — | — | WO | claimed |
| US-20050061750-A1 | Methods for the purification of contaminated waters | POLYMER VENTURES, INC. (US) | 2005-03-24 | — | — | US | claimed |
| EP-0621317-B1 | Azo compound and polarizing film using it | MITSUI CHEMICALS INC (JP) | 1998-12-16 | — | — | EP | claimed |
| EP-0688830-B1 | Azo compounds and polarizing films using the compounds | MITSUI CHEMICALS INC (JP) | 1998-11-18 | — | — | EP | claimed |
| US-5639809-A | AZO COMPOUND DISTRIBUTED IN POLYMER FILM; HEAT RESISTANCE | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-06-17 | — | — | US | claimed |
| EP-0688830-A1 | Azo compounds and polarizing films using the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1995-12-27 | — | — | EP | claimed |
| EP-0621317-A1 | Azo compound and polarizing film using it | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1994-10-26 | — | — | EP | claimed |
| US-4319252-A | Optical data storage and recording medium having a replaceable protective coverplate | DREXLER TECHNOLOGY CORPORATION (US) | 1982-03-09 | — | — | US | claimed |
| CN-118949667-B | Efficient composite desulfurizing agent and preparation method thereof | 明硕环境科技集团股份有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-118949667-B | Efficient composite desulfurizing agent and preparation method thereof | 明硕环境科技集团股份有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-115894965-B | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2024-12-10 | — | — | CN | disclosed |
| CN-115894965-B | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2024-12-10 | — | — | CN | disclosed |
| CN-115894965-B | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2024-12-10 | — | — | CN | disclosed |
| CN-118949667-A | Efficient composite desulfurizing agent and preparation method thereof | 明硕环境科技集团股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118949667-A | Efficient composite desulfurizing agent and preparation method thereof | 明硕环境科技集团股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118834321-A | Self-healing hydrogel-free material and preparation method and application thereof | 浙江大学 | 2024-10-25 | — | — | CN | disclosed |
| EP-4380924-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHIC FORMS OF AN ERBB AND BTK INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2024-06-12 | — | — | EP | disclosed |
| CN-117794902-A | Novel pharmaceutically acceptable salts and polymorphic forms of ErbB and BTK inhibitors | 迪哲(江苏)医药股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115716724-B | Concrete hydration synergist and preparation method thereof | 云南森博混凝土外加剂有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-115716724-B | Concrete hydration synergist and preparation method thereof | 云南森博混凝土外加剂有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-116075504-A | Crystalline forms of a compound | 深圳福沃药业有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-116018141-A | Salt and crystal form containing indole derivatives, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-112794507-B | Circulating water treatment method | 苏州清扬水处理工程有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-115894965-A | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2023-04-04 | — | — | CN | disclosed |
| CN-115894965-A | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2023-04-04 | — | — | CN | disclosed |
| CN-115894965-A | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2023-04-04 | — | — | CN | disclosed |
| CN-115716724-A | Concrete hydration synergist and preparation method thereof | 云南森博混凝土外加剂有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-115716724-A | Concrete hydration synergist and preparation method thereof | 云南森博混凝土外加剂有限公司 | 2023-02-28 | — | — | CN | disclosed |
| WO-2023011358-A1 | NOVEL PHARMACEUTICAL SALTS AND POLYMORPHIC FORMS OF AN ERBB AND BTK INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-02-09 | — | — | WO | disclosed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-113087892-B | Method and device for preparing polyether polyol | 万华化学集团股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| WO-2022105882-A1 | SALT AND CRYSTAL FORM OF INDOLE-CONTAINING DERIVATIVE, AND PREPARATION METHODS THEREFOR AND APPLICATIONS THEREOF | 上海翰森生物医药科技有限公司 | 2022-05-27 | — | — | WO | disclosed |
| WO-2022100641-A1 | PHARMACEUTICAL COMPOSITION CONTAINING EGFR INHIBITOR, AND PREPARATION METHOD THEREFOR | 上海海雁医药科技有限公司 | 2022-05-19 | — | — | WO | disclosed |
| CN-113891927-A | Paper sheet covering and method of making same | GPCP知识产权控股有限责任公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-113087892-A | Method and device for preparing polyether polyol | 万华化学集团股份有限公司 | 2021-07-09 | — | — | CN | disclosed |
| CN-110452221-A | (E)-N- { 4- [the chloro- 4- of 3- (2- pyridomethoxy) anilino-] -3- cyano -7- ethyoxyl -6- quinolyl } -4- (dimethylamino) -2- crotonamide maleate and crystalline form | WYETH LLC | 2019-11-15 | — | — | CN | disclosed |
| CN-109851617-A | Chemical entities, composition and method | 润新生物公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-109652037-A | A kind of high-temperature stable cement slurry and preparation method thereof | 中国海洋石油集团有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-108889282-A | Acrylamide-maleic anhydride graft copolymerization modified peanut shell, preparation method thereof and application of peanut shell as heavy metal ion adsorbent | 仲恺农业工程学院 | 2018-11-27 | — | — | CN | disclosed |
| CN-107949388-A | Pharmaceutical salts, physical aspect and composition of pyrrolopyrimidine kinase inhibitor and preparation method thereof | 艾森生物科学公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-104271268-B | Alcohol alcoxylates and its purposes in hard-surface cleaning preparaton | 巴斯夫欧洲公司 | 2017-11-17 | — | — | CN | disclosed |
| CN-107250338-A | Fabrid care composition comprising metathesized unsaturated polyol ester | 宝洁公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-104513200-B | Substituted crotonamide maleate and crystal forms thereof | 江苏苏中药业集团股份有限公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-104277142-B | The production method of narrow distribution low-molecular-weight polymeric thing | Changzhou University (CN) | 2017-01-04 | — | — | CN | disclosed |
| EP-3042718-A1 | DEVICE FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | Dietz, Ulrich (DE) | 2016-07-13 | — | — | EP | disclosed |
| CN-103038195-B | Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by micro-or nanoemulsification | ULRICH DIETZ (DE) | 2016-04-13 | — | — | CN | disclosed |
| EP-2585420-B1 | METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | DIETZ ULRICH (DE) | 2016-04-06 | — | — | EP | disclosed |
| CN-103086483-B | The method of purifying waste water and comprise the oil production technology of the method | GENERAL ELECTRIC COMPANY (US) | 2015-09-30 | — | — | CN | disclosed |
| CN-103360595-B | The method of induction time is shortened during the ring-opening polymerization of catalysis epoxidation thing in interrupter method | HUAIAN BUD POLYURETHANE SCIENCE & TECHNOLOGY CO.,LTD. (CN) | 2015-09-09 | — | — | CN | disclosed |
| CN-103360595-A | Method for shortening induction time during catalysis of ring opening polymerization of epoxide in discontinuous method | HUAIAN BUD POLYURETHANE SCIENCE AND TECHNOLOGY CO LTD | 2013-10-23 | — | — | CN | disclosed |
| CN-103130362-A | Water treatment device and method | GEN ELECTRIC | 2013-06-05 | — | — | CN | disclosed |
| CN-103086483-A | Water purification method and oil extraction process comprising water purification method | GEN ELECTRIC | 2013-05-08 | — | — | CN | disclosed |
| EP-2585420-A2 | DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | Dietz, Ulrich (DE) | 2013-05-01 | — | — | EP | disclosed |
| CN-103038195-A | Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by micro-or nanoemulsification | DIETZ ULRICH | 2013-04-10 | — | — | CN | disclosed |
| CN-102906155-A | Oligomerized ester alkoxylate compositions | DOW GLOBAL TECHNOLOGIES LLC | 2013-01-30 | — | — | CN | disclosed |
| WO-2011160857-A2 | DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION | DIETZ ULRICH (DE) | 2011-12-29 | — | — | WO | disclosed |
| EP-2399885-A1 | Device and method for solubilizing, separating, removing and reacting carboxylic acids in aqueous or organic solutions by means of micro- or nanoemulsification | Dietz, Ulrich (DE) | 2011-12-28 | — | — | EP | disclosed |
| CN-1989075-B | Cerium oxide powder and process for producing the same | LG CHEMICAL LTD | 2010-05-12 | — | — | CN | disclosed |
| US-20100042042-A1 | ENVIRONMENTAL STATE DETECTION WITH HYDROGEL BASED FULLY INTEGRATED TRANSDUCER DEVICE | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2010-02-18 | — | — | US | disclosed |
| CN-101523192-A | Environmental state detection with hydrogel-based fully integrated sensor device | KONINKL PHILIPS ELECTRONICS NV (NL) | 2009-09-02 | — | — | CN | disclosed |
| CN-100415800-C | Bimetallic cyanide catalyst for epoxide ring-opening polymerization | NANTONG HUIKE POLYAMINORESIN R (CN) | 2008-09-03 | — | — | CN | disclosed |
| CN-100412044-C | Method for producing alkanol alkoxylates at optimal reaction temperatures | BASF AG (DE) | 2008-08-20 | — | — | CN | disclosed |
| CN-100999573-A | Bimetallic cyanide catalyst for epoxide ring-opening polymerization | HUIKE POLYAMINORESIN RES & DEV (CN) | 2007-07-18 | — | — | CN | disclosed |
| CN-1989075-A | Cerium oxide powder and process for producing the same | LG CHEMICAL LTD (KR) | 2007-06-27 | — | — | CN | disclosed |
| CN-1296337-C | Alkoxylates with low residual alcohol content | BASF AG (DE) | 2007-01-24 | — | — | CN | disclosed |
| CN-1261478-C | Intergrated method for the production of polyurethane foams | BASF AG (DE) | 2006-06-28 | — | — | CN | disclosed |
| CN-1688528-A | Method for producing alkanol alkoxylates at optimal reaction temperatures | BASF AG (DE) | 2005-10-26 | — | — | CN | disclosed |
| CN-1688529-A | Alkoxylates exhibiting low residual alcohol content | BASF AG (DE) | 2005-10-26 | — | — | CN | disclosed |
| US-20050061750-A1 | Methods for the purification of contaminated waters | POLYMER VENTURES, INC. (US) | 2005-03-24 | — | — | US | disclosed |
| CN-1564836-A | Integral preparation of polyurethane foam | BASF AG (DE) | 2005-01-12 | — | — | CN | disclosed |
| EP-0621317-B1 | Azo compound and polarizing film using it | MITSUI CHEMICALS INC (JP) | 1998-12-16 | — | — | EP | disclosed |
| EP-0688830-B1 | Azo compounds and polarizing films using the compounds | MITSUI CHEMICALS INC (JP) | 1998-11-18 | — | — | EP | disclosed |
| US-5698682-A | HIGH HEAT RESISTANCE; EXCELLENT OPTICAL PROPERTIES; DICHROIC DYES | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-12-16 | — | — | US | disclosed |
| US-5639809-A | AZO COMPOUND DISTRIBUTED IN POLYMER FILM; HEAT RESISTANCE | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0688830-A1 | Azo compounds and polarizing films using the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1995-12-27 | — | — | EP | disclosed |
| EP-0621317-A1 | Azo compound and polarizing film using it | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1994-10-26 | — | — | EP | disclosed |
| US-4343879-A | LASERS | DREXLER TECHNOLOGY CORPORATION (US) | 1982-08-10 | — | — | US | disclosed |
| US-4319252-A | Optical data storage and recording medium having a replaceable protective coverplate | DREXLER TECHNOLOGY CORPORATION (US) | 1982-03-09 | — | — | US | disclosed |
| US-4088530-A | ADDING A COPOLYMER OF ACRYLAMIDE AND MALEIC ACID OR ANHYDRIDE TO AN AQUEOUS SOLUTION OF CELLULOSE FIBERS | BORDEN PRODUCTS LIMITED (CA) | 1978-05-09 | — | — | US | disclosed |
| US-4088530-A | ADDING A COPOLYMER OF ACRYLAMIDE AND MALEIC ACID OR ANHYDRIDE TO AN AQUEOUS SOLUTION OF CELLULOSE FIBERS | BORDEN PRODUCTS LIMITED (CA) | 1978-05-09 | — | — | US | disclosed |