Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27628189 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Fumaric Acid SCHEMBL27628190 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL27712629 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL1736261 | 1.00 | TSHR (0.69) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL28157708 | 0.97 | TSHR (0.65) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL28157707 | 0.97 | TSHR (0.65) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Fumaric Acid SCHEMBL8986950 | 0.94 | TSHR (0.61) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Maleic Acid SCHEMBL11169845 | 0.92 | TSHR (0.58) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Acrylic Acid SCHEMBL27727809 | 0.88 | LMNA (0.56) | TSHRALDH1A1FGFR4TP53EGLN1 | |
| Acrylic Acid SCHEMBL7140121 | 0.87 | ALDH1A1 (0.79) | TSHRALDH1A1FGFR4TP53EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894965-B | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2024-12-10 | — | — | CN | claimed |
| CN-115894965-A | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2023-04-04 | — | — | CN | claimed |
| WO-2022100641-A1 | PHARMACEUTICAL COMPOSITION CONTAINING EGFR INHIBITOR, AND PREPARATION METHOD THEREFOR | 上海海雁医药科技有限公司 | 2022-05-19 | — | — | WO | claimed |
| CN-103086483-B | The method of purifying waste water and comprise the oil production technology of the method | GENERAL ELECTRIC COMPANY (US) | 2015-09-30 | — | — | CN | claimed |
| CN-103086483-A | Water purification method and oil extraction process comprising water purification method | GEN ELECTRIC | 2013-05-08 | — | — | CN | claimed |
| WO-2005030652-A1 | METHODS FOR THE PURIFICATION OF CONTAMINATED WATERS | POLYMER VENTURES, INC. (US) | 2005-04-07 | — | — | WO | claimed |
| US-20050061750-A1 | Methods for the purification of contaminated waters | POLYMER VENTURES, INC. (US) | 2005-03-24 | — | — | US | claimed |
| EP-0621317-B1 | Azo compound and polarizing film using it | MITSUI CHEMICALS INC (JP) | 1998-12-16 | — | — | EP | claimed |
| EP-0688830-B1 | Azo compounds and polarizing films using the compounds | MITSUI CHEMICALS INC (JP) | 1998-11-18 | — | — | EP | claimed |
| US-5639809-A | AZO COMPOUND DISTRIBUTED IN POLYMER FILM; HEAT RESISTANCE | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-06-17 | — | — | US | claimed |
| EP-0688830-A1 | Azo compounds and polarizing films using the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1995-12-27 | — | — | EP | claimed |
| EP-0621317-A1 | Azo compound and polarizing film using it | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1994-10-26 | — | — | EP | claimed |
| US-4319252-A | Optical data storage and recording medium having a replaceable protective coverplate | DREXLER TECHNOLOGY CORPORATION (US) | 1982-03-09 | — | — | US | claimed |
| CN-115894965-B | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2024-12-10 | — | — | CN | disclosed |
| CN-115894965-B | Maleic acid acrylamide copolymerized hydrogel and preparation method thereof | 武汉轻工大学 | 2024-12-10 | — | — | CN | disclosed |
| CN-118834321-A | Self-healing hydrogel-free material and preparation method and application thereof | 浙江大学 | 2024-10-25 | — | — | CN | disclosed |
| EP-0621317-A1 | Azo compound and polarizing film using it | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1994-10-26 | — | — | EP | disclosed |
| US-4343879-A | LASERS | DREXLER TECHNOLOGY CORPORATION (US) | 1982-08-10 | — | — | US | disclosed |
| US-4319252-A | Optical data storage and recording medium having a replaceable protective coverplate | DREXLER TECHNOLOGY CORPORATION (US) | 1982-03-09 | — | — | US | disclosed |
| US-4088530-A | ADDING A COPOLYMER OF ACRYLAMIDE AND MALEIC ACID OR ANHYDRIDE TO AN AQUEOUS SOLUTION OF CELLULOSE FIBERS | BORDEN PRODUCTS LIMITED (CA) | 1978-05-09 | — | — | US | disclosed |