Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1736262 | 0.94 | TSHR (0.69) | TSHRALDH1A1FGFR4LMNATP53 | |
| Maleic Acid SCHEMBL27712629 | 0.94 | TSHR (0.69) | TSHRALDH1A1FGFR4LMNATP53 | |
| Fumaric Acid SCHEMBL27628189 | 0.94 | TSHR (0.69) | TSHRALDH1A1FGFR4LMNATP53 | |
| Fumaric Acid SCHEMBL27628190 | 0.94 | TSHR (0.69) | TSHRALDH1A1FGFR4LMNATP53 | |
| Maleic Acid SCHEMBL1736261 | 0.94 | TSHR (0.69) | TSHRALDH1A1FGFR4LMNATP53 | |
| Maleic Acid SCHEMBL28157707 | 0.92 | TSHR (0.65) | TSHRALDH1A1FGFR4LMNATP53 | |
| Maleic Acid SCHEMBL28157708 | 0.92 | TSHR (0.65) | TSHRALDH1A1FGFR4LMNATP53 | |
| Acrylic Acid SCHEMBL27727809 | 0.89 | LMNA (0.56) | TSHRALDH1A1FGFR4LMNATP53 | |
| Acrylic Acid SCHEMBL26086 | 0.88 | ALDH1A1 (0.79) | TSHRALDH1A1FGFR4LMNATP53 | |
| Maleic Acid SCHEMBL2425693 | 0.88 | LMNA (0.71) | TSHRALDH1A1FGFR4LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5520820-A | ACRYLAMIDE-ACRYLIC ACID-MALEIC ACID TERPOLYMER FLOCCULANT | ALLIED COLLOIDS LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |