Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.67 |
| ▸ | PRKDC | P78527 | 18/20 | 0.67 |
| ▸ | ABL1 | P00519 | 5/20 | 0.67 |
| ▸ | SRC | P12931 | 5/20 | 0.67 |
| ▸ | HCK | P08631 | 4/20 | 0.67 |
| ▸ | KDR | P35968 | 4/20 | 0.67 |
| ▸ | MTOR | P42345 | 4/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.67 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.67 |
| ▸ | EGFR | P00533 | 3/20 | 0.67 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.48 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17365228 | 0.82 | PDGFRB (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL28456717 | 0.71 | SRC (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL19356065 | 0.71 | PDGFRB (0.53) | PDGFRBPDGFRA | |
| SCHEMBL30387566 | 0.68 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL8326897 | 0.67 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL9566549 | 0.67 | PDGFRB (0.57) | PDGFRBPDGFRA | |
| SCHEMBL30955240 | 0.65 | ALDH1A1 (0.67) | PDGFRBPDGFRA | |
| SCHEMBL149180 | 0.65 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL28075509 | 0.65 | GRK6 (0.60) | PDGFRBPDGFRA | |
| SCHEMBL2211964 | 0.65 | ALDH1A1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160968-A1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | Rhizen Pharmaceuticals S.A. (CH) | 2017-05-03 | — | — | EP | claimed |
| WO-2015198289-A1 | SUBSTITUTED CHROMENE DERIVATIVES AS SELECTIVE DUAL INHIBITORS OF PI3 DELTA AND GAMMA PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2015-12-30 | — | — | WO | claimed |