Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10187102 | 0.85 | L3MBTL1 (0.60) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL12806451 | 0.83 | ACHE (0.56) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL22566468 | 0.83 | ACHE (0.60) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL8231646 | 0.79 | ACHE (0.56) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL1046460 | 0.79 | APLNR (0.63) | ALDH1A1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL9023705 | 0.79 | ACHE (0.56) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL12174283 | 0.79 | ACHE (0.56) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL95794 | 0.79 | ACHE (0.56) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL703143 | 0.79 | PDCD1 (0.56) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL15974038 | 0.79 | ACHE (0.50) | ACHEL3MBTL1KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160977-A2 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | The University of Kansas (US) | 2017-05-03 | — | — | EP | claimed |
| WO-2015200514-A2 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | THE UNIVERSITY OF KANSAS (US) | 2015-12-30 | — | — | WO | claimed |
| US-11708319-B2 | Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers | UNIVERSITY OF KANSAS (US) | 2023-07-25 | — | — | US | disclosed |
| US-20220041543-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | REATA PHARMACEUTICALS, INC. | 2022-02-10 | — | — | US | disclosed |
| US-20200270201-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | REATA PHARMACEUTICALS, INC. | 2020-08-27 | — | — | US | disclosed |
| US-10590065-B2 | Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers | UNIVERSITY OF KANSAS (US) | 2020-03-17 | — | — | US | disclosed |
| US-20180057446-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | REATA PHARMACEUTICALS, INC. | 2018-03-01 | — | — | US | disclosed |
| EP-3160977-A2 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | The University of Kansas (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015200514-A2 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | THE UNIVERSITY OF KANSAS (US) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057446-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | HSP90AB2P, HSP90AB1, HSP90AA1 | ACHE 1749/4885L3MBTL1 1721/4885KDM4E 2339/4885 |
| US-11708319-B2 | Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers | HSP90AB2P, HSP90AB1, HSPB1 | ACHE 1551/4885L3MBTL1 1727/4885KDM4E 2267/4885 |
| US-20220041543-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | HSP90AB2P, HSP90AB1, HSPB1 | ACHE 1551/4885L3MBTL1 1727/4885KDM4E 2267/4885 |
| US-20200270201-A1 | BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS | HSP90AB2P, HSP90AB1, HSPB1 | ACHE 1551/4885L3MBTL1 1727/4885KDM4E 2267/4885 |
| US-10590065-B2 | Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers | HSP90AB2P, HSP90AB1, HSP90AA1 | ACHE 1749/4885L3MBTL1 1721/4885KDM4E 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.