Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.78 |
| ▸ | NPC1 | O15118 | 8/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.78 |
| ▸ | RAB9A | P51151 | 7/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | TP53 | P04637 | 4/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.78 |
| ▸ | HPGD | P15428 | 4/20 | 0.78 |
| ▸ | XDH | P47989 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762092 | 0.88 | MAPT (1.00) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL28601511 | 0.87 | PIN1 (0.77) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL4745653 | 0.84 | PIN1 (0.73) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8481488 | 0.84 | PIN1 (0.73) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL20782412 | 0.81 | PIN1 (0.68) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL22445073 | 0.80 | PIN1 (0.67) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL28254050 | 0.80 | RAB9A (0.80) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL11730519 | 0.80 | PIN1 (0.67) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6560178 | 0.80 | PIN1 (0.66) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL29068825 | 0.79 | MAPT (0.80) | PIN1MAPTALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2388255-A1 | Polysubstituted benzofurans and medicinal applications thereof | Ikerchem, S.L. (ES) | 2011-11-23 | — | — | EP | claimed |
| US-8038466-B1 | Power receptacle with enlarged heat dissipation path formed on mating face and power connector assembly thereof | ALLTOP ELECTRONICS (SUZHOU) CO., LTD (CN) | 2011-10-18 | — | — | US | claimed |
| US-8835659-B2 | Polysubstituted benzofurans and medicinal applications thereof | IKERCHEM, S.L. (ES) | 2014-09-16 | — | — | US | disclosed |
| US-20130217730-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | IKERCHEM, S.L. (ES) | 2013-08-22 | — | — | US | disclosed |
| EP-2569292-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | Ikerchem, S.L. (ES) | 2013-03-20 | — | — | EP | disclosed |
| EP-2388255-A1 | Polysubstituted benzofurans and medicinal applications thereof | Ikerchem, S.L. (ES) | 2011-11-23 | — | — | EP | disclosed |
| WO-2011141458-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | IKERCHEM, S.L. (ES) | 2011-11-17 | — | — | WO | disclosed |
| US-8038466-B1 | Power receptacle with enlarged heat dissipation path formed on mating face and power connector assembly thereof | ALLTOP ELECTRONICS (SUZHOU) CO., LTD (CN) | 2011-10-18 | — | — | US | disclosed |
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |
| US-4022908-A | Use of certain 2-nitro-3-phenyl-alkoxybenzofurans in inhibiting growth of microorganisms and intermediates in the synthesis of said benzofurans | RIKER LABORATORIES, INC. (US) | 1977-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217730-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | AGER, TFEB, FPGS | PIN1 1761/4885MAPT 184/4885ALDH1A1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.