Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20608254 | 0.87 | ALDH1A1 (0.68) | ALDH1A1GPR52KEAP1FFAR1MAPT | |
| SCHEMBL3638330 | 0.87 | ALDH1A1 (0.62) | ALDH1A1GPR52KEAP1FFAR1MAPT | |
| SCHEMBL6515245 | 0.87 | ALDH1A1 (0.68) | ALDH1A1GPR52KEAP1FFAR1MAPT | |
| SCHEMBL6515248 | 0.87 | ALDH1A1 (0.68) | ALDH1A1GPR52KEAP1FFAR1MAPT | |
| SCHEMBL6521611 | 0.87 | ALDH1A1 (0.68) | ALDH1A1GPR52KEAP1FFAR1MAPT | |
| SCHEMBL28945946 | 0.81 | GPR52 (0.58) | ALDH1A1GPR52KEAP1FFAR1MAPT | |
| SCHEMBL14571875 | 0.81 | GPR52 (0.58) | ALDH1A1GPR52KEAP1FFAR1MAPT | |
| SCHEMBL11576204 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KEAP1FFAR1MAPTHTT | |
| SCHEMBL11576206 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KEAP1FFAR1MAPTHTT | |
| Benzylacetone SCHEMBL1346 | 0.80 | ALDH1A1 (1.00) | ALDH1A1KEAP1FFAR1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160008297-A1 | COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160008297-A1 | COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) | TRPV2, TRPV1, TRPM2 | ALDH1A1 2905/4885GPR52 310/4885KEAP1 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.