Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17429280 | 0.87 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HPGDGPR52KEAP1 | |
| SCHEMBL14571875 | 0.82 | GPR52 (0.58) | ALDH1A1SMN1; SMN2GPR52KEAP1FFAR1 | |
| SCHEMBL28945946 | 0.82 | GPR52 (0.58) | ALDH1A1SMN1; SMN2GPR52KEAP1FFAR1 | |
| SCHEMBL23929239 | 0.81 | GPR52 (0.56) | ALDH1A1SMN1; SMN2GPR52KEAP1FFAR1 | |
| SCHEMBL23929240 | 0.81 | GPR52 (0.56) | ALDH1A1SMN1; SMN2GPR52KEAP1FFAR1 | |
| SCHEMBL5229814 | 0.80 | CES1 (0.52) | ALDH1A1SMN1; SMN2HPGDMAPTHTT | |
| SCHEMBL6207002 | 0.78 | GPR52 (0.53) | ALDH1A1SMN1; SMN2HPGDGPR52KEAP1 | |
| SCHEMBL2322246 | 0.78 | KEAP1 (0.61) | ALDH1A1SMN1; SMN2GPR52KEAP1FFAR1 | |
| SCHEMBL14259536 | 0.78 | GPR52 (0.49) | ALDH1A1HPGDGPR52KEAP1FFAR1 | |
| SCHEMBL6990805 | 0.78 | GPR52 (0.49) | ALDH1A1HPGDGPR52KEAP1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410135-B2 | 4,5 dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators | SOLVAY PHARMACEUTICALS B.V. (NL) | 2013-04-02 | — | — | US | disclosed |
| US-8410135-B2 | 4,5 dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators | SOLVAY PHARMACEUTICALS B.V. (NL) | 2013-04-02 | — | — | US | disclosed |
| US-8410135-B2 | 4,5 dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators | SOLVAY PHARMACEUTICALS B.V. (NL) | 2013-04-02 | — | — | US | disclosed |
| EP-2158184-A2 | 4,5-DIHYDRO-(1H)-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR MODULATORS | Solvay Pharmaceuticals B.V. (NL) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008152086-A2 | 4,5-DIHYDRO-(1H)-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR MODULATORS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152086-A2 | 4,5-DIHYDRO-(1H)-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR MODULATORS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-18 | — | — | WO | disclosed |
| US-20080312276-A1 | 4,5 Dihydro-(1H)-Pyrazole Derivatives as Cannabinoid CB1 Receptor Modulators | SOLVAY PHARMACEUTICALS, B.V. | 2008-12-18 | — | — | US | disclosed |
| US-20080312276-A1 | 4,5 Dihydro-(1H)-Pyrazole Derivatives as Cannabinoid CB1 Receptor Modulators | SOLVAY PHARMACEUTICALS, B.V. | 2008-12-18 | — | — | US | disclosed |
| US-20080312276-A1 | 4,5 Dihydro-(1H)-Pyrazole Derivatives as Cannabinoid CB1 Receptor Modulators | SOLVAY PHARMACEUTICALS, B.V. | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312276-A1 | 4,5 Dihydro-(1H)-Pyrazole Derivatives as Cannabinoid CB1 Receptor Modulators | CNR1, CNR2, GPR35 | ALDH1A1 4160/4885SMN1; SMN2 1740/4885HPGD 1182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.