Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 2/20 | 0.41 |
| ▸ | EEF2 | P13639 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17434081 | 0.81 | EEF2K (0.39) | EEF2KEEF2ALDH1A1L3MBTL1PIK3CA | |
| SCHEMBL17434268 | 0.78 | PDE5A (0.39) | ALDH1A1L3MBTL1CYP2C9CYP2C19PDE4A | |
| SCHEMBL17433924 | 0.77 | EEF2K (0.45) | EEF2KALDH1A1KDM4ECYP2C9CYP2C19 | |
| SCHEMBL7627588 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4EL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL17434340 | 0.70 | KMT2A (0.58) | ALDH1A1KDM4EL3MBTL1P2RY12MAPK1 | |
| SCHEMBL6514548 | 0.69 | ALDH1A1 (0.54) | ALDH1A1KDM4EL3MBTL1MAPK1 | |
| SCHEMBL7436172 | 0.68 | CDK4 (0.46) | ALDH1A1KDM4EPIK3CACYP2C9CYP2C19 | |
| SCHEMBL11875375 | 0.68 | KMT2A (0.55) | CYP2C9CYP2C19PDE4B | |
| SCHEMBL4110648 | 0.68 | EEF2K (0.35) | EEF2KEEF2ALDH1A1KDM4EPIK3CA | |
| SCHEMBL4110652 | 0.68 | EEF2K (0.35) | EEF2KEEF2ALDH1A1KDM4EPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834520-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-05 | — | — | US | disclosed |
| US-20160229814-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-08-11 | — | — | US | disclosed |
| EP-2975031-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2016-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229814-A1 | HETEROCYCLIC COMPOUND | RORB, RORC, RORA | EEF2K 2197/4885EEF2 2000/4885ALDH1A1 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.