Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 3/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290764 | 0.79 | PLA2G2A (0.67) | PLA2G2ALMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2005738 | 0.77 | PLA2G2A (0.57) | PLA2G2APLA2G10PLA2G6PLA2G1BPLA2G5 | |
| SCHEMBL2004858 | 0.76 | PLA2G2A (0.58) | PLA2G2ALMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL27443583 | 0.76 | ALDH1A1 (0.63) | P2RX4LMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2002208 | 0.76 | FABP4 (0.50) | PLA2G2ALMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29904927 | 0.76 | P2RX4 (1.00) | P2RX4CYP19A1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14160818 | 0.76 | P2RX4 (1.00) | P2RX4CYP19A1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL612585 | 0.76 | POLB (0.62) | P2RX4PLA2G2ALMNACYP19A1KDM4E | |
| SCHEMBL27725617 | 0.75 | P2RX4 (0.54) | P2RX4LMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28158573 | 0.74 | P2RX4 (0.60) | P2RX4PLA2G2ALMNACYP19A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9573902-B2 | Process for the preparation of Ivacaftor and its intermediates | LAURUS LABS PRIVATE LTD. (IN) | 2017-02-21 | — | — | US | claimed |
| US-20160016909-A1 | PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES | LAURUS LABS LIMITED (IN) | 2016-01-21 | — | — | US | claimed |
| US-9573902-B2 | Process for the preparation of Ivacaftor and its intermediates | LAURUS LABS PRIVATE LTD. (IN) | 2017-02-21 | — | — | US | disclosed |
| US-20160016909-A1 | PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES | LAURUS LABS LIMITED (IN) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016909-A1 | PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES | SLC10A2, SLC26A4, SLC10A1 | P2RX4 595/4885PLA2G2A 3038/4885LMNA 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.