Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 3/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 11/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.46 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.44 |
| ▸ | PLA2G2F | Q9BZM2 | 2/20 | 0.44 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.44 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.44 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.44 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.44 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004182 | 0.92 | FABP4 (0.42) | FABP4PLA2G2APLA2G10PLA2G1BPLA2G2E | |
| SCHEMBL2007254 | 0.90 | PLA2G2A (0.42) | FABP4PLA2G2APLA2G10PLA2G1BPLA2G2E | |
| SCHEMBL2008576 | 0.88 | BID (0.41) | FABP4PLA2G2AKDM4EMAPT | |
| SCHEMBL2005799 | 0.82 | PLA2G2A (0.52) | FABP4PLA2G2APLA2G1B | |
| SCHEMBL2004088 | 0.82 | FABP4 (0.48) | FABP4PLA2G2ASMN1; SMN2LMNATSHR | |
| SCHEMBL2005738 | 0.80 | PLA2G2A (0.57) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D | |
| SCHEMBL27789965 | 0.80 | FABP4 (0.43) | FABP4PLA2G2APLA2G10PLA2G1BPLA2G2E | |
| SCHEMBL290764 | 0.76 | PLA2G2A (0.67) | PLA2G2ASMN1; SMN2LMNAKDM4EMEN1 | |
| SCHEMBL2004858 | 0.76 | PLA2G2A (0.58) | PLA2G2APLA2G10PLA2G1BPLA2G2ELMNA | |
| SCHEMBL17435239 | 0.76 | P2RX4 (0.59) | PLA2G2APLA2G10PLA2G1BPLA2G2EPLA2G2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| CN-101563337-A | Indole compounds | MICROBIA INC (US) | 2009-10-21 | — | — | CN | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | FABP4 559/4885PLA2G2A 3285/4885PLA2G10 2670/4885 |
| US-20070203209-A1 | Useful indole compounds | TPH2, HRH2, HRH1 | FABP4 3309/4885PLA2G2A 486/4885PLA2G10 737/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | FABP4 783/4885PLA2G2A 326/4885PLA2G10 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.