Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 10/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | F13A1 | P00488 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TGM1 | P22735 | 1/20 | 0.44 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613090 | 0.87 | TGM2 (0.65) | TGM2PTPN1PTPN11F13A1LMNA | |
| SCHEMBL31228347 | 0.87 | TGM2 (0.65) | TGM2PTPN1PTPN11F13A1LMNA | |
| SCHEMBL413017 | 0.80 | MMP1 (0.59) | TGM2PTPN1PTPN11LMNAKDM4E | |
| SCHEMBL29366956 | 0.80 | MMP1 (0.59) | TGM2PTPN1PTPN11LMNAKDM4E | |
| SCHEMBL2761954 | 0.80 | TGM2 (0.62) | TGM2PTPN1PTPN11F13A1LMNA | |
| SCHEMBL9357321 | 0.80 | TGM2 (0.57) | TGM2PTPN1PTPN11F13A1LMNA | |
| SCHEMBL23653363 | 0.78 | TGM2 (0.55) | TGM2PTPN1PTPN11F13A1LMNA | |
| SCHEMBL11883844 | 0.78 | TGM2 (0.55) | TGM2PTPN1PTPN11F13A1LMNA | |
| SCHEMBL3690870 | 0.78 | TGM2 (0.55) | TGM2PTPN1PTPN11F13A1LMNA | |
| SCHEMBL11808631 | 0.78 | EGFR (0.60) | TGM2PTPN1PTPN11F13A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016008411-A1 | 5-AMINO-4-CARBAMOYL-PYRAZOLE COMPOUNDS AS SELECTIVE AND IRREVERSIBLE T790M OVER WT-EGFR KINASE INHIBITORS AND USE THEREOF | BEIGENE, LTD. (KY) | 2016-01-21 | — | — | WO | disclosed |