Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17232558 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNATPSAB1PRSS1TPSD1 | |
| SCHEMBL19154486 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNATPSAB1PRSS1TPSD1 | |
| SCHEMBL22154185 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAHTTL3MBTL1MAPT | |
| SCHEMBL18430370 | 0.83 | L3MBTL1 (0.45) | SMN1; SMN2LMNATPSAB1PRSS1TPSD1 | |
| SCHEMBL19154445 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNATPSAB1PRSS1TPSD1 | |
| SCHEMBL6750273 | 0.82 | ALDH1A1 (0.58) | SMN1; SMN2LMNATPSAB1PRSS1TPSD1 | |
| SCHEMBL23901065 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNATPSAB1PRSS1HTT | |
| SCHEMBL17072452 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNATPSAB1PRSS1TPSD1 | |
| SCHEMBL19154501 | 0.81 | HTT (0.56) | SMN1; SMN2LMNATPSAB1PRSS1TPSD1 | |
| SCHEMBL614872 | 0.81 | LMNA (0.71) | SMN1; SMN2LMNAHTTL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016008112-A1 | LINKERS AND APPLICATION TOWARDS ADC THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2016-01-21 | — | — | WO | disclosed |