SCHEMBL17449595

SCHEMBL17449595

C[Si]1(C)C(c2cccc(-c3ccccn3)c2)=C(c2ccccc2)C(c2ccccc2)=C1c1cccc(-c2ccccn2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.43
HTR7 P34969 1/20 0.43
HRH3 Q9Y5N1 1/20 0.42
BACE1 P56817 1/20 0.41
CYP2A6 P11509 1/20 0.41
TLR4 O00206 1/20 0.40
TLR2 O60603 1/20 0.40
KDM4E B2RXH2 3/20 0.39
LMNA P02545 3/20 0.39
CCR1 P32246 2/20 0.39
CCR5 P51681 2/20 0.39
CCR8 P51685 2/20 0.39
CYP1A2 P05177 1/20 0.39
POLB P06746 1/20 0.39
METAP1 P53582 1/20 0.39
BLM P54132 1/20 0.39
HIF1A Q16665 1/20 0.39
DOHH Q9BU89 1/20 0.39
P4HTM Q9NXG6 1/20 0.39
KAT6A Q92794 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18327034 0.92 KDM4E (0.47) HTR1AHTR7HRH3BACE1CYP2A6
SCHEMBL7116753 0.85 KDM4E (0.46) CYP2A6KDM4ELMNACCR1CCR5
SCHEMBL6252273 0.83 KDM4E (0.41) CYP2A6KDM4ELMNACCR1CCR5
SCHEMBL127151 0.81 KDM4E (0.56) CYP2A6KDM4ELMNACCR1CCR5
SCHEMBL10038535 0.80 HPGDS (0.50) CYP2A6KDM4ELMNACCR1CCR5
SCHEMBL14413708 0.79 MAOA (0.40) HTR1AHTR7CYP2A6KDM4ECYP1A2
SCHEMBL29679578 0.79 KDM4E (0.62) HTR1AHTR7HRH3CYP2A6TLR4
SCHEMBL502867 0.79 KDM4E (0.62) HTR1AHTR7HRH3CYP2A6TLR4
SCHEMBL10018839 0.79 CYP2A6 (0.46) CYP2A6KDM4ELMNACCR1CCR5
SCHEMBL11954101 0.79 MEN1 (0.43) KDM4ELMNACCR1CCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9818955-B2 Compound, light emitting material, and organic light emitting device KYULUX, INC. (JP) 2017-11-14 US disclosed
US-20160020402-A1 COMPOUND, LIGHT EMITTING MATERIAL, AND ORGANIC LIGHT EMITTING DEVICE KYULUX, INC. (JP) 2016-01-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160020402-A1 COMPOUND, LIGHT EMITTING MATERIAL, AND ORGANIC LIGHT EMITTING DEVICE ARL1, CRY1, NR2E3 HTR1A 59/4885HTR7 322/4885HRH3 63/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.