SCHEMBL7116753

SCHEMBL7116753

C[Si]1(C)C(c2ccccn2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccccn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.46
LMNA P02545 7/20 0.46
CCR1 P32246 2/20 0.46
CCR5 P51681 2/20 0.46
CCR8 P51685 2/20 0.46
CYP1A2 P05177 2/20 0.46
HIF1A Q16665 2/20 0.46
POLB P06746 1/20 0.46
METAP1 P53582 1/20 0.46
BLM P54132 1/20 0.46
DOHH Q9BU89 1/20 0.46
P4HTM Q9NXG6 1/20 0.46
CYP2A6 P11509 1/20 0.43
RAB9A P51151 7/20 0.41
SMN1; SMN2 Q16637 7/20 0.41
TP53 P04637 5/20 0.41
NPC1 O15118 5/20 0.41
PKM P14618 3/20 0.41
NPY5R Q15761 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6252273 0.93 KDM4E (0.41) KDM4ELMNACCR1CCR5CCR8
SCHEMBL18385057 0.89 KDM4E (0.53) KDM4ELMNACCR1CCR5CCR8
SCHEMBL10018839 0.89 CYP2A6 (0.46) KDM4ELMNACCR1CCR5CCR8
SCHEMBL11954101 0.89 MEN1 (0.43) KDM4ELMNACCR1CCR5CCR8
SCHEMBL127151 0.89 KDM4E (0.56) KDM4ELMNACCR1CCR5CCR8
SCHEMBL17449595 0.85 HTR1A (0.43) KDM4ELMNACCR1CCR5CCR8
SCHEMBL6254371 0.84 KDM4E (0.42) KDM4ELMNACCR1CCR5CCR8
SCHEMBL7778273 0.84 KDM4E (0.42) KDM4ELMNACCR1CCR5CCR8
SCHEMBL10038535 0.84 HPGDS (0.50) KDM4ELMNACCR1CCR5CCR8
SCHEMBL6267426 0.83 CYP1A2 (0.43) KDM4ELMNACCR1CCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11807656-B2 Polycyclic aromatic compound and light emission layer-forming composition KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2023-11-07 US disclosed
US-11653565-B2 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2023-05-16 US disclosed
US-11637250-B2 Polycyclic aromatic compound and light emitting layer-forming composition KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2023-04-25 US disclosed
US-11539003-B2 Polycyclic aromatic amino compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2022-12-27 US disclosed
US-11342511-B2 Azoline ring-containing compound, electron transport/injection layer material containing the same, and organic electroluminescent element using the same SK MATERIALS JNC CO., LTD. (KR) 2022-05-24 US disclosed
US-20210395274-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2021-12-23 US disclosed
US-11136341-B2 Polycyclic aromatic compound and light emission layer-forming composition KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2021-10-05 US disclosed
US-10811613-B2 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2020-10-20 US disclosed
US-20200259089-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMITTING LAYER-FORMING COMPOSITION KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2020-08-13 US disclosed
US-20200220083-A1 POLYCYCLIC AROMATIC COMPOUND KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2020-07-09 US disclosed
US-20170261870-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING METHOD, AND IMAGE FORMING APPARATUS Konica Minolta, Inc. (JP) 2017-09-14 US disclosed
US-20170261870-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING METHOD, AND IMAGE FORMING APPARATUS Konica Minolta, Inc. (JP) 2017-09-14 US disclosed
EP-3109253-A1 POLYCYCLIC AROMATIC COMPOUND Kwansei Gakuin Educational Foundation (JP) 2016-12-28 EP disclosed
US-20150236274-A1 POLYCYCLIC AROMATIC COMPOUND KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2015-08-20 US disclosed
US-20070207343-A1 Organic Electroluminescent Device IDEMITSU KOSAN CO., LTD. (JP) 2007-09-06 US disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11539003-B2 Polycyclic aromatic amino compound BCAT2, BCAT1, SLC7A5 KDM4E 672/4885LMNA 3544/4885CCR1 3019/4885
US-11807656-B2 Polycyclic aromatic compound and light emission layer-forming composition ARNT, TYR, NLRP3 KDM4E 510/4885LMNA 499/4885CCR1 1160/4885
US-20150236274-A1 POLYCYCLIC AROMATIC COMPOUND PAH, ALK, AOC2 KDM4E 1365/4885LMNA 2487/4885CCR1 3574/4885
US-11653565-B2 Polycyclic aromatic compound ETV6, EBPL, EML4 KDM4E 719/4885LMNA 1955/4885CCR1 1898/4885
US-20200259089-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMITTING LAYER-FORMING COMPOSITION C9, TYR, CCNA1 KDM4E 775/4885LMNA 1171/4885CCR1 868/4885
US-10811613-B2 Polycyclic aromatic compound ETV6, PAH, EBPL KDM4E 905/4885LMNA 2276/4885CCR1 2673/4885
US-11342511-B2 Azoline ring-containing compound, electron transport/injection layer material containing the same, and organic electroluminescent element using the same SLC7A5, EML4, ARNT KDM4E 776/4885LMNA 1407/4885CCR1 1267/4885
US-11637250-B2 Polycyclic aromatic compound and light emitting layer-forming composition C9, TYR, CCNA1 KDM4E 775/4885LMNA 1171/4885CCR1 868/4885
US-11136341-B2 Polycyclic aromatic compound and light emission layer-forming composition TYR, NOD2, AHR KDM4E 1412/4885LMNA 518/4885CCR1 566/4885
US-20200220083-A1 POLYCYCLIC AROMATIC COMPOUND ETV6, EBPL, EML4 KDM4E 719/4885LMNA 1955/4885CCR1 1898/4885
US-20210395274-A1 POLYCYCLIC AROMATIC COMPOUND AND LIGHT EMISSION LAYER-FORMING COMPOSITION ARNT, TYR, NLRP3 KDM4E 510/4885LMNA 499/4885CCR1 1160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.