Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17467165 | 0.81 | POLB (0.35) | L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL17467171 | 0.80 | L3MBTL1 (0.36) | KDM4EL3MBTL1HTTSMN1; SMN2LMNA | |
| SCHEMBL15545684 | 0.79 | KDM4E (0.40) | KDM4EL3MBTL1HTTPOLBLMNA | |
| SCHEMBL15545096 | 0.78 | KDM4E (0.39) | KDM4EL3MBTL1HTTPOLBALDH1A1 | |
| SCHEMBL17467122 | 0.73 | BACE1 (0.37) | KDM4EL3MBTL1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17467147 | 0.72 | PAX8 (0.37) | KDM4EL3MBTL1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL67698 | 0.72 | POLB (0.41) | POLBSMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL15270753 | 0.67 | KDM4E (0.47) | KDM4EL3MBTL1HTTPOLBLMNA | |
| SCHEMBL30623532 | 0.66 | LMNA (0.43) | KDM4EHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL15990641 | 0.65 | HTT (0.35) | KDM4EL3MBTL1HTTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249160-B2 | Orexin receptor antagonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |