SCHEMBL17467846

SCHEMBL17467846

CSCO[C@@H]1[C@@H]2O[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OC[C@H]2O[C@H]1n1cnc2c(=O)[nH]c(NC(=O)OCC3c4ccccc4-c4ccccc43)nc21

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.40
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ TAS1R3 Q7RTX0 2/20 0.36
▸ TAS1R1 Q7RTX1 2/20 0.36
▸ KDM4E B2RXH2 1/20 0.35
▸ HINT1 P49773 3/20 0.34
▸ TAAR1 Q96RJ0 1/20 0.32
▸ GSK3A P49840 2/20 0.31
▸ RPS6KA3 P51812 2/20 0.31
▸ MAPK14 Q16539 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1970429 0.88 PDE4A (0.38) —
SCHEMBL12729593 0.85 KDM4E (0.41) ALDH1A1MEN1KMT2ATAS1R3TAS1R1
SCHEMBL10276358 0.84 CTSK (0.33) —
SCHEMBL16392690 0.78 KDM4E (0.42) ALDH1A1MEN1KMT2ATAS1R3TAS1R1
SCHEMBL9964276 0.77 TAS1R3 (0.43) ALDH1A1MEN1KMT2ATAS1R3TAS1R1
SCHEMBL12434623 0.75 ALDH1A1 (0.42) ALDH1A1MEN1KMT2ATAS1R3TAS1R1
SCHEMBL15060563 0.75 ALDH1A1 (0.42) ALDH1A1MEN1KMT2ATAS1R3TAS1R1
SCHEMBL20215731 0.75 TAS1R3 (0.46) ALDH1A1MEN1KMT2ATAS1R3TAS1R1
SCHEMBL19509704 0.75 PRMT6 (0.42) —
SCHEMBL15850632 0.75 TAS1R3 (0.46) ALDH1A1MEN1KMT2ATAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10287313-B2 RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2019-05-14 — — US disclosed
US-20160340382-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2016-11-24 — — US disclosed
EP-2334692-B1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS UNIV MCGILL (CA) 2016-04-13 — — EP disclosed
US-9249175-B2 RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2016-02-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10287313-B2 RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays EFTUD2, RNMT, NSUN2 ALDH1A1 199/4885MEN1 4069/4885KMT2A 1798/4885
US-20160340382-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS EFTUD2, RNMT, RNGTT ALDH1A1 212/4885MEN1 4163/4885KMT2A 1746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback