Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19322238 | 0.91 | PDE3B (0.45) | PDE3BPDE3AKDM4EMAPTTDP1 | |
| SCHEMBL19322244 | 0.83 | PDE3B (0.39) | PDE3BPDE3AKDM4EMAPTTDP1 | |
| SCHEMBL19322243 | 0.83 | NCOA1 (0.41) | PDE3BPDE3AKDM4EMAPTTDP1 | |
| SCHEMBL19322240 | 0.81 | MTNR1A (0.42) | PDE3BPDE3AKDM4EMAPTTDP1 | |
| SCHEMBL19322239 | 0.81 | L3MBTL1 (0.51) | PDE3BPDE3AKDM4EMAPTTDP1 | |
| SCHEMBL19322241 | 0.81 | PDE3B (0.39) | PDE3BPDE3AKDM4EMAPTTDP1 | |
| SCHEMBL17469286 | 0.78 | BCHE (0.36) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL19317490 | 0.77 | GAA (0.37) | KDM4EMAPTGAANPSR1ALDH1A1 | |
| SCHEMBL19322245 | 0.77 | KDM4E (0.40) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL19317487 | 0.74 | MEN1 (0.36) | KDM4EMAPTMAPK1CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11147795-B2 | Neuroprotective compounds and methods of use | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-10-19 | — | — | US | disclosed |
| US-20190350902-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-11-21 | — | — | US | disclosed |
| US-10358438-B2 | [3+2] annulation to produce 5-membered heterocyclic compounds | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-07-23 | — | — | US | disclosed |
| US-20170253580-A1 | ORGANIC REACTIONS | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-09-07 | — | — | US | disclosed |
| WO-2016014426-A1 | ORGANIC REACTIONS | THE ARIZONA BOARD OF REGENTS (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11147795-B2 | Neuroprotective compounds and methods of use | RTN3, CHRNB3, ARRB1 | PDE3B 3591/4885PDE3A 3508/4885KDM4E 3636/4885 |
| US-20170253580-A1 | ORGANIC REACTIONS | MYC, CYP2E1, CYP3A4 | PDE3B 4035/4885PDE3A 4473/4885KDM4E 1249/4885 |
| US-20190350902-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | RTN3, CHRNB3, ARRB1 | PDE3B 3591/4885PDE3A 3508/4885KDM4E 3636/4885 |
| US-10358438-B2 | [3+2] annulation to produce 5-membered heterocyclic compounds | ACR, MYC, TOP1 | PDE3B 3517/4885PDE3A 3993/4885KDM4E 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.