Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19322238 | 0.91 | PDE3B (0.45) | PDE3BPDE3ALMNAL3MBTL1MPO | |
| SCHEMBL19322241 | 0.88 | PDE3B (0.39) | NCOA1NCOA3PDE3BPDE3AMTNR1A | |
| SCHEMBL19322244 | 0.87 | PDE3B (0.39) | PDE3BPDE3AMTNR1ALMNAL3MBTL1 | |
| SCHEMBL19322239 | 0.86 | L3MBTL1 (0.51) | PDE3BPDE3AMTNR1ALMNAL3MBTL1 | |
| SCHEMBL19322240 | 0.86 | MTNR1A (0.42) | PDE3BPDE3AHTR2BMTNR1ALMNA | |
| SCHEMBL17469284 | 0.83 | PDE3B (0.39) | PDE3BPDE3ALMNAL3MBTL1MPO | |
| SCHEMBL19317489 | 0.82 | MEN1 (0.34) | IDO1TDO2KDM4EMEN1KMT2A | |
| SCHEMBL19322245 | 0.81 | KDM4E (0.40) | PDE3BPDE3AKDM4ERAB9AMEN1 | |
| SCHEMBL19317487 | 0.77 | MEN1 (0.36) | KDM4EMAPK1MEN1KMT2AMAPT | |
| SCHEMBL19322108 | 0.77 | ALDH1A1 (0.49) | MTNR1AL3MBTL1MTNR1BKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220031659-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2022-02-03 | — | — | US | disclosed |
| US-11147795-B2 | Neuroprotective compounds and methods of use | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-10-19 | — | — | US | disclosed |
| US-20190350902-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-11-21 | — | — | US | disclosed |
| US-10358438-B2 | [3+2] annulation to produce 5-membered heterocyclic compounds | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-07-23 | — | — | US | disclosed |
| US-20170253580-A1 | ORGANIC REACTIONS | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11147795-B2 | Neuroprotective compounds and methods of use | RTN3, CHRNB3, ARRB1 | NCOA1 125/4885NCOA3 35/4885PDE3B 3591/4885 |
| US-20170253580-A1 | ORGANIC REACTIONS | MYC, CYP2E1, CYP3A4 | NCOA1 892/4885NCOA3 696/4885PDE3B 4035/4885 |
| US-20190350902-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | RTN3, CHRNB3, ARRB1 | NCOA1 125/4885NCOA3 35/4885PDE3B 3591/4885 |
| US-10358438-B2 | [3+2] annulation to produce 5-membered heterocyclic compounds | ACR, MYC, TOP1 | NCOA1 1399/4885NCOA3 1076/4885PDE3B 3517/4885 |
| US-20220031659-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | SMN1; SMN2, BDNF, PYGB | NCOA1 2895/4885NCOA3 2363/4885PDE3B 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.