Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 4/20 | 0.54 |
| ▸ | MPI | P34949 | 11/20 | 0.53 |
| ▸ | PHOSPHO1 | Q8TCT1 | 11/20 | 0.53 |
| ▸ | PMM2 | O15305 | 10/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 4/20 | 0.53 |
| ▸ | IDE | P14735 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18913005 | 0.87 | G6PD (0.60) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL1895902 | 0.77 | MPI (0.60) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL8372604 | 0.76 | MPI (0.72) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL8624454 | 0.73 | G6PD (0.66) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL18845247 | 0.73 | G6PD (0.66) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL8371733 | 0.72 | G6PD (0.64) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL8373401 | 0.70 | G6PD (0.72) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL8370675 | 0.70 | MPI (0.61) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL8373005 | 0.70 | G6PD (1.00) | G6PDMPIPHOSPHO1PMM2APOBEC3G | |
| SCHEMBL24327539 | 0.70 | G6PD (0.60) | G6PDMPIPHOSPHO1PMM2APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | WASHINGTON UNIVERSITY (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | UNIV WASHINGTON (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | IMPDH1, IMPDH2, SHMT2 | G6PD 13/4885MPI 10/4885PHOSPHO1 342/4885 |
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | IMPDH1, IMPDH2, SHMT2 | G6PD 13/4885MPI 10/4885PHOSPHO1 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.