SCHEMBL18913005

SCHEMBL18913005

O=C(O)c1ccccc1-n1sc2ccccc2c1=O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PD P11413 6/20 0.60
PMM2 O15305 7/20 0.58
MPI P34949 7/20 0.58
PHOSPHO1 Q8TCT1 6/20 0.58
APOBEC3G Q9HC16 5/20 0.58
PKM P14618 3/20 0.58
TDP1 Q9NUW8 3/20 0.58
ALDH1A1 P00352 3/20 0.58
KDM4E B2RXH2 2/20 0.58
MAPT P10636 2/20 0.58
HPGD P15428 2/20 0.58
ALOX12 P18054 2/20 0.58
CASP3 P42574 2/20 0.58
NPSR1 Q6W5P4 2/20 0.58
HSP90AA1 P07900 1/20 0.58
IDE P14735 2/20 0.56
MEN1 O00255 1/20 0.51
HCRTR1 O43613 1/20 0.51
POLB P06746 1/20 0.51
GFER P55789 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17502097 0.87 G6PD (0.54) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL1895902 0.82 MPI (0.60) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL18845247 0.79 G6PD (0.66) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL26645117 0.76 MPI (0.64) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL8624454 0.76 G6PD (0.66) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL8373401 0.76 G6PD (0.72) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL8372604 0.76 MPI (0.72) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL18913002 0.75 MPI (0.73) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL1898397 0.74 MPI (1.00) G6PDPMM2MPIPHOSPHO1APOBEC3G
SCHEMBL30562926 0.74 MPI (1.00) G6PDPMM2MPIPHOSPHO1APOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11801262-B2 Antibiotic compositions THIOREDOXIN SYSTEMS AB (SE) 2023-10-31 US disclosed
US-11013730-B1 Composition comprising selenazol or thiazalone derivatives and silver and method of treatment therewith THIOREDOXIN SYSTEMS AB (SE) 2021-05-25 US disclosed
US-20200281967-A1 Antibiotic Compositions THIOREDOXIN SYSTEMS AB (SE) 2020-09-10 US disclosed
US-10653717-B2 Antibiotic compositions THIOREDOXIN SYSTEMS AB (SE) 2020-05-19 US disclosed
US-20190307726-A1 PHARMACEUTICAL FORMULATIONS MOLECULAR DEFENSES CORP (US) 2019-10-10 US disclosed
US-20180185410-A1 Antibiotic Compositions THIOREDOXIN SYSTEMS AB (SE) 2018-07-05 US disclosed
WO-2017091737-A1 PHARMACEUTICAL FORMULATIONS Molecular Defenses Corporation (US) 2017-06-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190307726-A1 PHARMACEUTICAL FORMULATIONS GSS, GSR, MGST3 G6PD 672/4885PMM2 4390/4885MPI 2231/4885
US-20200281967-A1 Antibiotic Compositions MRPL21, RPS5, MRPS35 G6PD 3030/4885PMM2 2715/4885MPI 750/4885
US-20180185410-A1 Antibiotic Compositions MRPL21, RPS5, MRPS35 G6PD 3030/4885PMM2 2715/4885MPI 750/4885
US-11013730-B1 Composition comprising selenazol or thiazalone derivatives and silver and method of treatment therewith SELENOI, TST, SCLY G6PD 1736/4885PMM2 4644/4885MPI 1930/4885
US-10653717-B2 Antibiotic compositions MRPL21, RPS5, MRPS35 G6PD 3030/4885PMM2 2715/4885MPI 750/4885
US-11801262-B2 Antibiotic compositions MRPL21, RPS5, MRPS35 G6PD 3030/4885PMM2 2715/4885MPI 750/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.