Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6135895 | 0.90 | NPC1 (0.33) | NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10448205 | 0.81 | NPC1 (0.45) | NOTUMNPC1RAB9ALMNAGAA | |
| SCHEMBL8915564 | 0.81 | NOTUM (0.44) | NOTUMNPC1RAB9ALMNAGAA | |
| SCHEMBL343082 | 0.80 | DAPK3 (0.40) | NOTUMPTGS1PGR | |
| SCHEMBL135941 | 0.80 | SMN1; SMN2 (0.42) | USP1WDR48NPC1RAB9ALMNA | |
| SCHEMBL9360045 | 0.77 | ALDH1A1 (0.38) | — | |
| SCHEMBL15984285 | 0.76 | NISCH (0.44) | NOTUMPGR | |
| SCHEMBL342824 | 0.75 | PDE3B (0.37) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6699746 | 0.74 | NPC1 (0.35) | NPC1RAB9AGAAPGRSMN1; SMN2 | |
| SCHEMBL6699179 | 0.73 | TSHR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160052937-A1 | Tetrahydroimidazo[1,5-d][1,4]oxazepine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052937-A1 | Tetrahydroimidazo[1,5-d][1,4]oxazepine compound | GRIN1, GRM1, CACNA1D | USP1 3133/4885WDR48 1402/4885NOTUM 2394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.