SCHEMBL6135895

SCHEMBL6135895

O=C1CN=C(c2ccc(C3=NCC(=O)O3)cc2)O1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.31
NOTUM Q6P988 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8915564 0.90 NOTUM (0.44) NPC1RAB9ASMN1; SMN2NOTUM
SCHEMBL17512909 0.90 USP1 (0.37) NPC1RAB9ASMN1; SMN2NOTUM
SCHEMBL10448205 0.90 NPC1 (0.45) NPC1RAB9ASMN1; SMN2NOTUM
SCHEMBL135941 0.89 SMN1; SMN2 (0.42) NPC1RAB9ASMN1; SMN2
SCHEMBL9360045 0.85 ALDH1A1 (0.38)
SCHEMBL6699746 0.83 NPC1 (0.35) NPC1RAB9ASMN1; SMN2
SCHEMBL6699179 0.82 TSHR (0.35)
SCHEMBL343082 0.81 DAPK3 (0.40) NOTUM
SCHEMBL5855957 0.80 GSTP1 (0.46) SMN1; SMN2NOTUM
SCHEMBL834917 0.78 NPC1 (0.36) NPC1RAB9ASMN1; SMN2NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0329396-B1 Polymeric polymethine dyes and optical data storage media containing same MINNESOTA MINING & MFG (US) 1994-09-14 EP claimed
US-4948715-A HEAT AND STORAGE STABLE, NONDIFFUSING MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-08-14 US claimed
EP-0737231-B2 THERMAL STABILIZED RESIN COMPOSITIONS KOLON INC (KR) 2005-11-02 EP disclosed
US-6951905-B2 Reacting a bisoxazolone with a diamine terminated oligomer in a solvent at a temperature of < 80 degrees c QINETIQ LIMITED (GB) 2005-10-04 US disclosed
EP-1250376-B1 PROCESS FOR PREPARING BISOXAZOLONE BASED POLYMERS QINETIQ LTD (GB) 2005-08-31 EP disclosed
US-20040068059-A1 Aliphatic polyester copolymer and process for producing the same, biodegradable resin molding based on aliphatic polyester, and lactone-containing resin DAICEL CHEMICAL INDUSTRIES LTD. (JP) 2004-04-08 US disclosed
EP-1354908-A1 ALIPHATIC POLYESTER COPOLYMER AND PROCESS FOR PRODUCING THE SAME, BIODEGRADABLE RESIN MOLDING BASED ON ALIPHATIC POLYESTER, AND LACTONE-CONTAINING RESIN DAICEL CHEMICAL INDUSTRIES, Ltd. (JP) 2003-10-22 EP disclosed
US-20030158349-A1 Bisoxazolone based polymers QINETIQ LIMITED (GB) 2003-08-21 US disclosed
EP-1250376-A1 BISOXAZOLONE BASED POLYMERS QinetiQ Limited (GB) 2002-10-23 EP disclosed
WO-2001055244-A1 BISOXAZOLONE BASED POLYMERS QINETIQ LIMITED (GB) 2001-08-02 WO disclosed
EP-0710684-B1 Preparation process of polyhydroxycarboxylic acid MITSUI CHEMICALS INC (JP) 2001-01-31 EP disclosed
US-4785070-A THERMAL CYCLODEHYDRATION OF AN AZLACTONE OR 4,4-DISUBSTITUTED 2-OXAZOLIN-5-ONE AND DIAMINE; WATER SOLUBILITY MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1988-11-15 US disclosed
US-4705824-A Poly(5-imidazolone) and process therefor W. R. GRACE & CO. (US) 1987-11-10 US disclosed
US-4684601-A UNSATURATED, HIGH MOLECULAR WEIGHT DAINIPPON INK AND CHEMICALS, INC. (JP) 1987-08-04 US disclosed
US-4640887-A C,M UNSATURATED POLYESTERS WITH FREE CARBOXY GROUPS; PRINTING DURABLE PLATES WITH IMPROVED OLEOPHILICITY DAINIPPON INK AND CHEMICALS, INC. (JP) 1987-02-03 US disclosed
EP-0185493-A2 Imidazolinone-containing polymers and copolymers MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1986-06-25 EP disclosed
US-4591545-A Photosensitive image-forming material having a layer of photosensitive polyester modified with chain extender DAINIPPON INK AND CHEMICALS, INC. (JP) 1986-05-27 US disclosed
EP-0019061-B1 PROCESS FOR PRODUCING AROMATIC POLYESTERS HAVING INCREASED DEGREES OF POLYMERIZATION AND MOULDED ARTICLES COMPOSED OF THESE POLYESTERS TEIJIN LIMITED (JP) 1984-08-08 EP disclosed
US-4291152-A CHAIN EXTENSION WITH BICYCLIC OXAZINONE OR OXAZOLONE TEIJIN LIMITED (JP) 1981-09-22 US disclosed
EP-0019061-A1 Process for producing aromatic polyesters having increased degrees of polymerization and moulded articles composed of these polyesters TEIJIN LIMITED (JP) 1980-11-26 EP disclosed