Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17513876 | 0.84 | GRM5 (0.39) | GRM5NPC1RAB9ARPS6KB1PARP1 | |
| SCHEMBL17513904 | 0.81 | GPR52 (0.43) | NPC1RAB9ASMN1; SMN2GPR52PARP1 | |
| SCHEMBL17513938 | 0.80 | CA12 (0.39) | NPC1RAB9AGPR52PARP1ALDH1A1 | |
| SCHEMBL17514002 | 0.80 | RAB9A (0.40) | GRM5NPC1RAB9AFAAHSMN1; SMN2 | |
| SCHEMBL17513922 | 0.77 | NPC1 (0.38) | NPC1RAB9ADAGLAGPR52KDM4E | |
| SCHEMBL17513966 | 0.76 | GRM5 (0.43) | GRM5NPC1RAB9ASMN1; SMN2PARP1 | |
| SCHEMBL17513894 | 0.76 | ALOX5 (0.36) | NPC1RAB9AFAAHGPR52PARP1 | |
| SCHEMBL17513952 | 0.73 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL17514012 | 0.72 | FFAR1 (0.37) | NPC1RAB9ASMN1; SMN2GPR52ALDH1A1 | |
| SCHEMBL17513978 | 0.70 | ATM (0.41) | GRM5NPC1RAB9ARPS6KB1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197482-A1 | METHODS OF TREATING TRAUMATIC BRAIN INJURY | Oxeia Biopharmaceuticals Inc. (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-3182992-A1 | METHODS OF TREATING MILD BRAIN INJURY | Oxeia Biopharmaceuticals Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2016048488-A1 | METHODS OF TREATING TRAUMATIC BRAIN INJURY | OXEIA BIOPHARMACEUTICALS, INC. (US) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016028826-A1 | METHODS OF TREATING MILD BRAIN INJURY | OXEIA BIOPHARMACEUTICALS, INC. (US) | 2016-02-25 | — | — | WO | disclosed |