SCHEMBL17514975

SCHEMBL17514975

COc1[c]cccc1-c1cccc(Cl)c1F

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 1/20 0.39
MAPK14 Q16539 1/20 0.39
KMO O15229 2/20 0.35
CTSA P10619 2/20 0.34
UTRN P46939 1/20 0.33
CCR4 P51679 1/20 0.32
HTR2C P28335 1/20 0.32
NMUR2 Q9GZQ4 1/20 0.31
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31
PKM P14618 1/20 0.31
RAB9A P51151 1/20 0.31
CTSD P07339 1/20 0.31
BACE1 P56817 1/20 0.31
FABP4 P15090 1/20 0.30
FABP5 Q01469 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8992649 0.83 NUDT1 (0.38) NPC1RAB9AL3MBTL1
SCHEMBL3645412 0.83 CTSA (0.33) CTSANPC1RAB9A
SCHEMBL9453855 0.83 CYP2A6 (0.38) MAPK14HTR2CNPC1RAB9AL3MBTL1
SCHEMBL17514642 0.81 AR (0.34)
SCHEMBL17514792 0.81 ORAI1 (0.34)
SCHEMBL17514753 0.81 OXTR (0.34) CTSA
SCHEMBL17514995 0.78 HTR1A (0.37) HTR2C
SCHEMBL17514655 0.78 HSD11B1 (0.41) MAPK14FABP4FABP5
SCHEMBL17514594 0.78 KMO (0.34) KMOCCR4
SCHEMBL15637578 0.78 KMO (0.39) MAPK10MAPK14KMOHTR2CNMUR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016026830-A1 NOVEL FUNGICIDAL PYRAZOLE DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-02-25 WO disclosed