Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16886321 | 0.94 | HSD11B1 (0.57) | HSD11B1CYP11B2BLMKDM4EALOX15 | |
| SCHEMBL16219016 | 0.88 | CYP11B2 (0.49) | HSD11B1CYP11B2BLMKDM4EALOX15 | |
| SCHEMBL17518824 | 0.85 | CYP11B2 (0.54) | HSD11B1CYP11B2PRMT5WDR77BLM | |
| SCHEMBL28154388 | 0.84 | HSD11B1 (0.48) | HSD11B1CYP11B2BLMKDM4EALOX15 | |
| SCHEMBL12413775 | 0.84 | ALDH1A1 (0.56) | HSD11B1ALDH1A1LMNAMAPTPROKR1 | |
| SCHEMBL16144645 | 0.82 | HSD11B1 (0.50) | HSD11B1CYP11B2PRMT5WDR77BLM | |
| SCHEMBL15528763 | 0.81 | NAMPT (0.63) | LMNAMAPTNAMPT | |
| SCHEMBL25767313 | 0.81 | CYP11B2 (0.49) | HSD11B1CYP11B2PRMT5WDR77BLM | |
| SCHEMBL24059287 | 0.80 | CYP11B2 (0.57) | HSD11B1CYP11B2PRMT5WDR77BLM | |
| SCHEMBL31339129 | 0.79 | GPR119 (0.56) | HSD11B1CYP11B2PRMT5WDR77BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046581-A1 | Factor XIa Inhibitors | F11, F12, TFPI | HSD11B1 1600/4885CYP11B2 1926/4885PRMT5 1688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.