Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30716573 | 1.00 | GCGR (0.58) | GCGRLMNADHODHNPC1RAB9A | |
| SCHEMBL14282780 | 0.87 | GCGR (0.58) | GCGRLMNADHODHNPC1RAB9A | |
| SCHEMBL1752471 | 0.86 | GCGR (0.57) | GCGRLMNADHODHNPC1RAB9A | |
| SCHEMBL1751492 | 0.86 | GCGR (0.57) | GCGRLMNADHODHNPC1RAB9A | |
| SCHEMBL30414624 | 0.86 | GCGR (0.57) | GCGRLMNADHODHNPC1RAB9A | |
| SCHEMBL10153184 | 0.85 | GCGR (0.43) | GCGRDHODH | |
| SCHEMBL1752147 | 0.85 | GCGR (0.56) | GCGRLMNADHODHNPC1RAB9A | |
| SCHEMBL14248583 | 0.84 | GCGR (0.43) | GCGRLMNADHODHALDH1A1FPR2 | |
| SCHEMBL945897 | 0.84 | GCGR (0.55) | GCGRLMNADHODHNPC1RAB9A | |
| SCHEMBL4756219 | 0.83 | GCGR (0.54) | GCGRLMNADHODHNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402118-A | Preparation method of rosuvastatin calcium intermediate | 江苏阿尔法集团福瑞药业(宿迁)有限公司 | 2024-01-16 | — | — | CN | claimed |
| CN-112174898-B | Novel method for preparing hydroxypyrimidine by continuously oxidizing dihydropyrimidinone | 浙江宏元药业股份有限公司 | 2021-05-04 | — | — | CN | claimed |
| CN-112174898-A | Novel method for preparing hydroxypyrimidine by continuously oxidizing dihydropyrimidinone | 浙江宏元药业股份有限公司 | 2021-01-05 | — | — | CN | claimed |
| CN-117402118-A | Preparation method of rosuvastatin calcium intermediate | 江苏阿尔法集团福瑞药业(宿迁)有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117402118-A | Preparation method of rosuvastatin calcium intermediate | 江苏阿尔法集团福瑞药业(宿迁)有限公司 | 2024-01-16 | — | — | CN | disclosed |
| US-11084013-B1 | Metal-free catalytic oxidation system, an oxygenation method and a method for producing benzoic acid derivatives | ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) | 2021-08-10 | — | — | US | disclosed |
| CN-112174898-B | Novel method for preparing hydroxypyrimidine by continuously oxidizing dihydropyrimidinone | 浙江宏元药业股份有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-112174898-A | Novel method for preparing hydroxypyrimidine by continuously oxidizing dihydropyrimidinone | 浙江宏元药业股份有限公司 | 2021-01-05 | — | — | CN | disclosed |
| EP-2598484-B1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LEK PHARMACEUTICALS (SI) | 2016-06-29 | — | — | EP | disclosed |
| US-9085538-B2 | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof | LEK PHARMACEUTICALS D.D. (SI) | 2015-07-21 | — | — | US | disclosed |
| CN-103864697-A | Preparation method of rosuvastatin intermediate main chain alcohol | RUNZE PHARMACEUTICAL SUZHOU CO LTD | 2014-06-18 | — | — | CN | disclosed |
| CN-100349877-C | Preparation of aminopyrimidine compounds. | ASTRAZENECA UK LTD (GB) | 2007-11-21 | — | — | CN | disclosed |
| CN-1301977-C | Process for preparing aminopyrimidine compounds | ASTRA ZENECA BRITISH CO LTD (GB) | 2007-02-28 | — | — | CN | disclosed |
| EP-1417180-B1 | PREPARATION OF AMINOPYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2006-12-27 | — | — | EP | disclosed |
| CN-1763016-A | Preparation of aminopyrimidine compounds. | ASTRAZENECA UK LTD (GB) | 2006-04-26 | — | — | CN | disclosed |
| EP-1417180-A4 | PREPARATION OF AMINOPYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2004-10-27 | — | — | EP | disclosed |
| US-20040176401-A1 | Preparation of aminopyrimidine compounds | ASTRAZENECA UK LIMITED (GB) | 2004-09-09 | — | — | US | disclosed |
| CN-1527821-A | Process for preparing aminopyrimidine compounds | — | 2004-09-08 | — | — | CN | disclosed |
| EP-1417180-A1 | PREPARATION OF AMINOPYRIMIDINE COMPOUNDS | Astrazeneca UK Limited (GB) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003006439-A1 | PREPARATION OF AMINOPYRIMIDINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2003-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176401-A1 | Preparation of aminopyrimidine compounds | DPYD, IDH3B, UMPS | GCGR 3928/4885LMNA 4017/4885DHODH 229/4885 |
| US-11084013-B1 | Metal-free catalytic oxidation system, an oxygenation method and a method for producing benzoic acid derivatives | DUOX2, HAO2, DUOX1 | GCGR 3897/4885LMNA 3563/4885DHODH 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.