Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589 | 0.87 | ALDH1A1 (0.44) | GCGRNPC1RAB9AALOX5MAPK14 | |
| SCHEMBL10129581 | 0.86 | DHODH (0.44) | GCGRDHODHRXFP1ALDH1A1MAPT | |
| SCHEMBL1751791 | 0.84 | GCGR (0.58) | GCGRLMNADHODHSMN1; SMN2NPC1 | |
| SCHEMBL17613417 | 0.84 | LMNA (0.49) | GCGRLMNADHODHSMN1; SMN2NPC1 | |
| SCHEMBL14282780 | 0.84 | GCGR (0.58) | GCGRLMNADHODHSMN1; SMN2NPC1 | |
| SCHEMBL30716573 | 0.84 | GCGR (0.58) | GCGRLMNADHODHSMN1; SMN2NPC1 | |
| SCHEMBL13916565 | 0.82 | GCGR (0.50) | GCGRLMNADHODHSMN1; SMN2RXFP1 | |
| SCHEMBL1752471 | 0.82 | GCGR (0.57) | GCGRLMNADHODHSMN1; SMN2NPC1 | |
| SCHEMBL30414624 | 0.82 | GCGR (0.57) | GCGRLMNADHODHSMN1; SMN2NPC1 | |
| SCHEMBL1751492 | 0.82 | GCGR (0.57) | GCGRLMNADHODHSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703944-B2 | Method for preparing rosuvastatin calcium intermediate | PORTON FINE CHEMICALS LTD. (CN) | 2014-04-22 | — | — | US | disclosed |
| US-20130143908-A1 | METHOD FOR PREPARING ROSUVASTATIN CALCIUM INTERMEDIATE | PORTON FINE CHEMICALS LTD. (CN) | 2013-06-06 | — | — | US | disclosed |
| US-7872012-B2 | Pyrimidinone compounds and preparation and use thereof | Zhejiang Hisun Pharma Co., Ltd. (CN) | 2011-01-18 | — | — | US | disclosed |
| US-7872012-B2 | Pyrimidinone compounds and preparation and use thereof | Zhejiang Hisun Pharma Co., Ltd. (CN) | 2011-01-18 | — | — | US | disclosed |
| EP-1845092-B1 | PYRIMIDINONE COMPOUNDS, THEIR PREPARATION AND USE THEREOF | YAO HUI (CN) | 2010-09-01 | — | — | EP | disclosed |
| US-20080280930-A1 | Pyrimidinone Compounds and Preparation and Use Thereof | Yao, Hui (CN) | 2008-11-13 | — | — | US | disclosed |
| US-20080280930-A1 | Pyrimidinone Compounds and Preparation and Use Thereof | Yao, Hui (CN) | 2008-11-13 | — | — | US | disclosed |
| WO-2008059519-A2 | A PROCESS FOR THE PREPARATION OF INTERMEDIATES OF ROSUVASTATIN | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2008-05-22 | — | — | WO | disclosed |
| US-7371759-B2 | HMG-CoA reductase inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371759-B2 | HMG-CoA reductase inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-13 | — | — | US | disclosed |
| US-20080009622-A1 | METHOD FOR PRODUCING PYRIMIDINE COMPOUND | AJINOMOTO CO., INC. (JP) | 2008-01-10 | — | — | US | disclosed |
| EP-1849765-A1 | METHOD FOR PRODUCING PYRIMIDINE COMPOUND | Ajinomoto Co., Inc. (JP) | 2007-10-31 | — | — | EP | disclosed |
| EP-1845092-A1 | PYRIMIDINONE COMPOUNDS, THEIR PREPARATION AND USE THEREOF | Yao, Hui (CN) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007074391-A2 | PREPARATION OF A KEY INTERMEDIATE IN THE SYNTHESIS OF ROSUVASTATIN | KHAMAR BAKULESH MAFATLAL (IN) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007074391-A2 | PREPARATION OF A KEY INTERMEDIATE IN THE SYNTHESIS OF ROSUVASTATIN | KHAMAR BAKULESH MAFATLAL (IN) | 2007-07-05 | — | — | WO | disclosed |
| WO-2004103977-A2 | PROCESS FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2004-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009622-A1 | METHOD FOR PRODUCING PYRIMIDINE COMPOUND | TYMS, TYMP, UMPS | GCGR 3126/4885LMNA 3372/4885DHODH 19/4885 |
| US-20080280930-A1 | Pyrimidinone Compounds and Preparation and Use Thereof | HMGCR, PSEN1, DHPS | GCGR 1827/4885LMNA 769/4885DHODH 26/4885 |
| US-20130143908-A1 | METHOD FOR PREPARING ROSUVASTATIN CALCIUM INTERMEDIATE | HMGCR, PCSK9, CACNA1E | GCGR 3145/4885LMNA 613/4885DHODH 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.