Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5906542 | 0.99 | HPGD (0.45) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| Maleic Acid SCHEMBL5906530 | 0.90 | MCL1 (0.43) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL1752534 | 0.82 | HTR2A (0.41) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL4850625 | 0.80 | HSD17B10 (0.49) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL7345457 | 0.78 | HPGD (0.47) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL22868261 | 0.78 | HTR2A (0.47) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL7345010 | 0.77 | HSD17B10 (0.46) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL30040327 | 0.77 | HSD17B10 (0.46) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL9431800 | 0.73 | MCL1 (0.49) | HPGDHSD17B10ALDH1A1USP2HTR2A | |
| SCHEMBL9635353 | 0.72 | DRD2 (0.59) | HPGDHSD17B10ALDH1A1USP2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909576-A2 | NOVEL PHARMACEUTICAL COMPOUNDS | Concert Pharmaceuticals Inc. (US) | 2008-04-16 | — | — | EP | claimed |
| US-20070191381-A1 | Novel pharmaceutical compounds | CONCERT PHARMACEUTICALS INC. (US) | 2007-08-16 | — | — | US | claimed |
| US-20070037815-A1 | Novel pharmaceutical compounds | CONCERT PHARMACEUTICALS, INC. | 2007-02-15 | — | — | US | claimed |
| WO-2007016361-A2 | NOVEL PHARMACEUTICAL COMPOUNDS | CONCERT PHARMACEUTICALS INC. (US) | 2007-02-08 | — | — | WO | claimed |
| US-20060040929-A1 | (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and method of preparation thereof | MCCALL ROBERT B | 2006-02-23 | — | — | US | claimed |
| EP-1569649-A2 | USE OF HETEROCYCLIC AMINE-TYPE COMPOUNDS AS NEUROPROTECTIVE AGENTS | Pharmacia & Upjohn Company LLC (US) | 2005-09-07 | — | — | EP | claimed |
| US-6921771-B2 | Method of treating sexual disturbances | PHARMACIA & UPJOHN COMPANY (US) | 2005-07-26 | — | — | US | claimed |
| US-6903127-B2 | Method of treating sexual disturbances | PHARMACIA & UPJOHN COMPANY (US) | 2005-06-07 | — | — | US | claimed |
| US-6890945-B2 | Method of treating sexual disturbances | PHARMACIA & UPJOHN COMPANY (US) | 2005-05-10 | — | — | US | claimed |
| US-20040266812-A1 | (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione | PHARMACIA & UPJOHN COMPANY | 2004-12-30 | — | — | US | claimed |
| US-20040214826-A1 | Method of treating sexual disturbances | PHARMACIA & UPJOHN COMPANY | 2004-10-28 | — | — | US | claimed |
| US-20040214825-A1 | treating sexual disorders using (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione | PHARMACIA & UPJOHN COMPANY | 2004-10-28 | — | — | US | claimed |
| US-20040142937-A1 | Use of heterocyclic amine-type compounds as neuroprotective agents | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | claimed |
| WO-2004037971-A2 | USE OF HETEROCYCLIC AMINE-TYPE COMPOUNDS AS NEUROPROTECTIVE AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-05-06 | — | — | WO | claimed |
| US-20040029909-A1 | (5R)-5-(methyamino)-5, 6-dihydro-4H-imidazo[4,5,1,-ij]quinoline-2(1H)-thione | ACKER BRAD A (US) | 2004-02-12 | — | — | US | claimed |
| US-20020137763-A1 | (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione | PHARMACIA & UPJOHN COMPANY | 2002-09-26 | — | — | US | claimed |
| US-6455564-B1 | ORAL ADMINISTRATION OF (5R)-(METHYLAMINO)-5,6-DIHYDRO-4H-IMIDAZO(4,5,1-IJ)QUINOLIN-2( '1H)-ONE OR -THIONE | PHARMACIA & UPJOHN COMPANY | 2002-09-24 | — | — | US | claimed |
| WO-2001083483-A1 | (5R)-(METHYLAMINO)-5,6-DIHYDRO-4H-IMIDAZO[4,5,1-ij]QUINOLINE-2(1H)-THIONE | PHARMACIA & UPJOHN COMPANY (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1140092-A2 | METHOD OF TREATING SEXUAL DISTURBANCES | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000040226-A2 | METHOD OF TREATING SEXUAL DISTURBANCES | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-13 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214825-A1 | treating sexual disorders using (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione | SULT1A1, CYP19A1, SHBG | HPGD 296/4885HSD17B10 533/4885ALDH1A1 136/4885 |
| US-20070037815-A1 | Novel pharmaceutical compounds | PDE12, PDE5A, PDE3B | HPGD 88/4885HSD17B10 262/4885ALDH1A1 1292/4885 |
| US-20040214826-A1 | Method of treating sexual disturbances | CYP19A1, CYP17A1, CYP21A2 | HPGD 378/4885HSD17B10 397/4885ALDH1A1 220/4885 |
| US-20020137763-A1 | (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione | QDPR, UGT1A4, CYP3A5 | HPGD 1353/4885HSD17B10 2026/4885ALDH1A1 188/4885 |
| US-20040142937-A1 | Use of heterocyclic amine-type compounds as neuroprotective agents | NLN, GAP43, BDNF | HPGD 280/4885HSD17B10 3595/4885ALDH1A1 521/4885 |
| US-20040029909-A1 | (5R)-5-(methyamino)-5, 6-dihydro-4H-imidazo[4,5,1,-ij]quinoline-2(1H)-thione | CYP3A5, QDPR, SCN5A | HPGD 997/4885HSD17B10 2324/4885ALDH1A1 340/4885 |
| US-20060040929-A1 | (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione and method of preparation thereof | CYP3A5, UGT1A1, SULT1A1 | HPGD 278/4885HSD17B10 1105/4885ALDH1A1 208/4885 |
| US-20040266812-A1 | (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione | CYP3A5, UGT1A4, QDPR | HPGD 1424/4885HSD17B10 2014/4885ALDH1A1 259/4885 |
| US-20070191381-A1 | Novel pharmaceutical compounds | PDE12, PDE5A, PDE3B | HPGD 88/4885HSD17B10 262/4885ALDH1A1 1292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.