Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.34 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.34 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.34 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22070158 | 0.96 | TAAR1 (0.46) | TAAR1LTA4HRAB9ASMN1; SMN2MMP3 | |
| SCHEMBL19375787 | 0.90 | LTA4H (0.44) | TAAR1LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24797599 | 0.87 | REN (0.46) | RENKMT2A | |
| SCHEMBL25854493 | 0.87 | REN (0.46) | RENKMT2A | |
| SCHEMBL17531777 | 0.86 | MEN1 (0.44) | MMP3RENKMT2A | |
| SCHEMBL29449848 | 0.86 | CTRB1 (0.39) | TAAR1LTA4HMMP2CTRB1 | |
| SCHEMBL17531811 | 0.84 | NAMPT (0.39) | NPC1RAB9ASMN1; SMN2MMP3REN | |
| SCHEMBL19037005 | 0.83 | TAAR1 (0.35) | TAAR1LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30302156 | 0.81 | MDM4 (0.39) | — | |
| SCHEMBL19318327 | 0.81 | TAAR1 (0.43) | TAAR1LTA4HNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10682371-B2 | Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof | YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOGY CO. LTD. (CN) | 2020-06-16 | — | — | US | disclosed |
| US-10682371-B2 | Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof | YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOGY CO. LTD. (CN) | 2020-06-16 | — | — | US | disclosed |
| US-20170266308-A1 | SMALL MOLECULE CONJUGATES SPECIFICALLY ACTIVATED IN TUMOR MICROENVIROMENT FOR TARGETING AND USE THEREOF | YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOGY CO. LTD. (CN) | 2017-09-21 | — | — | US | disclosed |
| US-20170266308-A1 | SMALL MOLECULE CONJUGATES SPECIFICALLY ACTIVATED IN TUMOR MICROENVIROMENT FOR TARGETING AND USE THEREOF | YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOGY CO. LTD. (CN) | 2017-09-21 | — | — | US | disclosed |
| US-20170266308-A1 | SMALL MOLECULE CONJUGATES SPECIFICALLY ACTIVATED IN TUMOR MICROENVIROMENT FOR TARGETING AND USE THEREOF | YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOGY CO. LTD. (CN) | 2017-09-21 | — | — | US | disclosed |
| EP-3184540-A1 | SPECIFICALLY ACTIVATED MICROMOLECULAR TARGET COUPLING BODY IN TUMOR MICROENVIRONMENT AND USE THEREOF | Yafei Shanghai Biolog Medicine Science& Technology (CN) | 2017-06-28 | — | — | EP | disclosed |
| EP-3184540-A1 | SPECIFICALLY ACTIVATED MICROMOLECULAR TARGET COUPLING BODY IN TUMOR MICROENVIRONMENT AND USE THEREOF | Yafei Shanghai Biolog Medicine Science& Technology (CN) | 2017-06-28 | — | — | EP | disclosed |
| WO-2016026458-A1 | SPECIFICALLY ACTIVATED MICROMOLECULAR TARGET COUPLING BODY IN TUMOR MICROENVIRONMENT AND USE THEREOF | 亚飞（上海）生物医药科技有限公司 | 2016-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170266308-A1 | SMALL MOLECULE CONJUGATES SPECIFICALLY ACTIVATED IN TUMOR MICROENVIROMENT FOR TARGETING AND USE THEREOF | CD4, MET, TNFSF10 | TAAR1 3225/4885LTA4H 733/4885NPC1 3985/4885 |
| US-10682371-B2 | Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof | MET, ARG1, CD4 | TAAR1 3812/4885LTA4H 486/4885NPC1 4472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.