Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12193903 | 0.74 | MAOA (0.41) | RAB9AKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL30986852 | 0.74 | MAOA (0.41) | RAB9AKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL21972244 | 0.70 | ALDH1A1 (0.47) | SLC6A2SLC6A4SLC6A3RAB9AKDM4E | |
| SCHEMBL3731249 | 0.69 | ALOX5 (0.35) | RAB9AKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL3738688 | 0.68 | MAPT (0.47) | SLC6A2SLC6A4SLC6A3RAB9ANPC1 | |
| Bromide SCHEMBL27619257 | 0.67 | MAPT (0.46) | SLC6A2SLC6A4SLC6A3RAB9ANPC1 | |
| SCHEMBL12264201 | 0.67 | MAOA (0.46) | SLC6A2SLC6A4RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5028728 | 0.66 | ALDH1A1 (0.34) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 | |
| SCHEMBL3743379 | 0.66 | DRD2 (0.39) | RAB9AKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL23668098 | 0.65 | NNMT (0.50) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981883-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007086800-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |