SCHEMBL17544600

SCHEMBL17544600

OCc1ccccc1Nc1nc(Cl)ncc1Br

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 9/20 0.51
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
MAPK8 P45983 3/20 0.41
CDK19 Q9BWU1 1/20 0.40
ALK Q9UM73 1/20 0.40
MAPK9 P45984 1/20 0.39
MAPK10 P53779 1/20 0.39
NTRK1 P04629 1/20 0.38
LRRK2 Q5S007 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
GSK3B P49841 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30088390 1.00 IGF1R (0.51) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL25056307 0.86 MEN1 (0.52) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL6176285 0.83 IGF1R (0.48) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL17544687 0.81 IGF1R (0.55) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL30833628 0.81 IGF1R (0.46) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL30833796 0.81 IGF1R (0.46) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL26506627 0.80 IGF1R (0.68) IGF1RMAPK8CDK19ALKGSK3B
SCHEMBL32684519 0.78 KMT2A (0.41) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL30833802 0.78 IGF1R (0.55) IGF1RMEN1KMT2AMAPK8CDK19
SCHEMBL24260666 0.78 IGF1R (0.55) IGF1RMEN1KMT2AMAPK8CDK19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230135635-A1 INHIBITORS OF ULK1/2 AND METHODS OF USING SAME Sanford Burnham Prebys Medical Discovery Institute 2023-05-04 US disclosed
US-20230135635-A1 INHIBITORS OF ULK1/2 AND METHODS OF USING SAME Sanford Burnham Prebys Medical Discovery Institute 2023-05-04 US disclosed
US-20230135635-A1 INHIBITORS OF ULK1/2 AND METHODS OF USING SAME Sanford Burnham Prebys Medical Discovery Institute 2023-05-04 US disclosed
CN-115515589-A ULK1/2 inhibitors and methods of use thereof 萨克生物研究学院 2022-12-23 CN disclosed
EP-4103182-A1 INHIBITORS OF ULK1/2 AND METHODS OF USING SAME Salk Institute for Biological Studies (US) 2022-12-21 EP disclosed
EP-4070795-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME Salk Institute for Biological Studies (US) 2022-10-12 EP disclosed
EP-3185868-B1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INST FOR BIOLOGICAL STUDI (US) 2022-04-06 EP disclosed
WO-2021163629-A1 INHIBITORS OF ULK1/2 AND METHODS OF USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2021-08-19 WO disclosed
WO-2021163629-A1 INHIBITORS OF ULK1/2 AND METHODS OF USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2021-08-19 WO disclosed
US-10774092-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2020-09-15 US disclosed
US-20190284207-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-09-19 US disclosed
US-20190248806-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-08-15 US disclosed
US-20190152989-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-05-23 US disclosed
US-10266549-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2019-04-23 US disclosed
US-20170342088-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2017-11-30 US disclosed
US-20170342088-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2017-11-30 US disclosed
US-20170342088-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2017-11-30 US disclosed
EP-3185868-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME Salk Institute for Biological Studies (US) 2017-07-05 EP disclosed
WO-2016033100-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2016-03-03 WO disclosed
WO-2016033100-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2016-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10266549-B2 ULK1 inhibitors and methods using same ULK1, ULK2, ULK3 IGF1R 1213/4885MEN1 1586/4885KMT2A 3395/4885
US-20230135635-A1 INHIBITORS OF ULK1/2 AND METHODS OF USING SAME ULK2, ULK1, ULK3 IGF1R 2282/4885MEN1 2093/4885KMT2A 3058/4885
US-20170342088-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 IGF1R 1164/4885MEN1 2139/4885KMT2A 3500/4885
US-20190248806-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 IGF1R 1164/4885MEN1 2139/4885KMT2A 3500/4885
US-20190152989-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 IGF1R 1164/4885MEN1 2139/4885KMT2A 3500/4885
US-10774092-B2 ULK1 inhibitors and methods using same ULK1, ULK2, ULK3 IGF1R 1213/4885MEN1 1586/4885KMT2A 3395/4885
US-20190284207-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 IGF1R 1164/4885MEN1 2139/4885KMT2A 3500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.