Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 11/20 | 0.70 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1824133 | 0.98 | ALDH1A1 (0.75) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Hydrochloric Acid SCHEMBL3278043 | 0.96 | ALDH1A1 (0.79) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL15164180 | 0.86 | CHKA (0.83) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL11693463 | 0.83 | CHKA (0.63) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzyl Viologen SCHEMBL4079047 | 0.82 | ALDH1A1 (0.71) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL28611338 | 0.81 | CHKA (0.61) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL365151 | 0.81 | CHKA (0.61) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL13283227 | 0.81 | CHKA (0.61) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL8857808 | 0.81 | CHKA (0.57) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL367939 | 0.80 | ALDH1A1 (0.63) | ALDH1A1KDM4ERAB9ACHKALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2982245-B1 | CYANINE DYES FOR LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS | ENZO LIFE SCIENCES INC (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-1885718-B1 | FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE | LIFE TECHNOLOGIES CORP (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9366676-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2016-06-14 | — | — | US | disclosed |
| EP-2982245-A1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | Enzo Life Sciences, Inc. (US) | 2016-02-10 | — | — | EP | disclosed |
| US-20150316558-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | MOLECULAR PROBES, INC. | 2015-11-05 | — | — | US | disclosed |
| EP-2381783-B1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | ENZO LIFE SCIENCES INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-9115397-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2015-08-25 | — | — | US | disclosed |
| US-20150004597-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | LIFE TECHNOLOGIES CORP (US) | 2015-01-01 | — | — | US | disclosed |
| US-8865904-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2014-10-21 | — | — | US | disclosed |
| US-8674102-B2 | Fluorescent dyes | ENZO LIFE SCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| WO-2010065918-A1 | LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS | ENZO LIFE SCIENCES, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-7598390-B2 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use | Life Technologies Corporation (US) | 2009-10-06 | — | — | US | disclosed |
| US-20090226954-A1 | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits | ENZO LIFE SCIENCES, INC. | 2009-09-10 | — | — | US | disclosed |
| EP-1885718-A1 | FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE | Molecular Probes, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006124816-A1 | FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE | MOLECULAR PROBES, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| US-20060263844-A1 | Flourescent chemical compounds having high selectivity for double standard DNA, and methods for their use | MOLECULAR PROBES, INC. | 2006-11-23 | — | — | US | disclosed |
| EP-1015433-B1 | SUBSTITUTED 1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3-BENZAZOCINE-10-OLES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-05-26 | — | — | EP | disclosed |
| US-6455538-B1 | SODIUM CHANNEL MODULATORS; BRAIN AND NERVOUS SYSTEM DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-09-24 | — | — | US | disclosed |
| EP-1015433-A1 | SUBSTITUTED 1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3-BENZAZOCINE-10-OLES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999014199-A1 | SUBSTITUTED 1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3-BENZAZOCINE-10-OLES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226954-A1 | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits | SSBP1, IMMT, DNAJA3 | CHKA 1419/4885ACHE 4522/4885ALDH1A1 4074/4885 |
| US-20150316558-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | POLRMT, DNA2, NSUN2 | CHKA 2846/4885ACHE 4710/4885ALDH1A1 2461/4885 |
| US-20150004597-A1 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use | POLRMT, DNA2, NSUN2 | CHKA 2846/4885ACHE 4710/4885ALDH1A1 2461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.