Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 12/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15164180 | 0.93 | CHKA (0.83) | CHKARAB9AKDM4EALDH1A1BCHE | |
| SCHEMBL13587655 | 0.84 | CHKA (0.70) | CHKARAB9AKDM4EALDH1A1BCHE | |
| SCHEMBL24663298 | 0.83 | CHKA (0.68) | CHKARAB9AKDM4EALDH1A1BCHE | |
| SCHEMBL1824133 | 0.82 | ALDH1A1 (0.75) | CHKARAB9AKDM4EALDH1A1 | |
| SCHEMBL15031465 | 0.81 | CHKA (0.65) | CHKARAB9AKDM4EALDH1A1BCHE | |
| SCHEMBL23373046 | 0.81 | KDM4E (0.67) | CHKARAB9AKDM4EALDH1A1BCHE | |
| Hydrochloric Acid SCHEMBL3278043 | 0.80 | ALDH1A1 (0.79) | CHKARAB9AKDM4EALDH1A1 | |
| Bromide SCHEMBL1757103 | 0.80 | ALDH1A1 (0.72) | CHKARAB9AKDM4EALDH1A1BCHE | |
| SCHEMBL18775289 | 0.79 | RAB9A (0.60) | CHKARAB9AKDM4EALDH1A1ACHE | |
| SCHEMBL4400715 | 0.78 | CHRNA7 (0.68) | CHKARAB9AKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178678-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069432-A1 | Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA5, CHRNA4 | CHKA 332/4885RAB9A 920/4885KDM4E 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.