Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | RAB9A | P51151 | 1/20 | 0.79 |
| ▸ | CHKA | P35790 | 10/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1824133 | 0.98 | ALDH1A1 (0.75) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL1757103 | 0.96 | ALDH1A1 (0.72) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL15164180 | 0.86 | CHKA (0.83) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Hydrochloric Acid SCHEMBL5155076 | 0.83 | ALDH1A1 (0.61) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Benzyl Viologen SCHEMBL1930045 | 0.82 | ALDH1A1 (0.78) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Hydrochloric Acid SCHEMBL636283 | 0.81 | LMNA (0.63) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Hydrochloric Acid SCHEMBL2460504 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL13283227 | 0.81 | CHKA (0.61) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Hydrochloric Acid SCHEMBL10935706 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL367939 | 0.80 | ALDH1A1 (0.63) | ALDH1A1KDM4ERAB9ACHKALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700780-B2 | Zwitterionic chromophores and macromolecules containing such chromophores | Wang, Zhi Yuan (CA) | 2010-04-20 | — | — | US | disclosed |
| US-7592358-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| EP-1686130-B1 | Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents | PFIZER PROD INC (US) | 2009-02-18 | — | — | EP | disclosed |
| US-20070161666-A1 | Pyrrolo[2,3-d]pyrimidine compounds | PFIZER INC | 2007-07-12 | — | — | US | disclosed |
| US-7192963-B2 | Pyrrolo[2,3-d]pyrimidine compounds | PFIZER INC (US) | 2007-03-20 | — | — | US | disclosed |
| EP-1742939-A2 | NOVEL ALKYNE COMPOUNDS EXHIBITING AN MCH ANTAGONISTIC EFFECT AND DRUGS CONTAINING SAID COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-17 | — | — | EP | disclosed |
| EP-1740572-A1 | NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS CONTAINING SAID COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| EP-1737823-A2 | NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS COMPRISING SAID COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2007-01-03 | — | — | EP | disclosed |
| US-20060199951-A1 | Zwitterionic chromophores and macromolecules containing such chromophores | WANG ZHI Y | 2006-09-07 | — | — | US | disclosed |
| EP-1686130-A1 | Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents | Pfizer Products Incorporated (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20030220353-A1 | Pyrrolo[2,3-d]pyrimidine compounds | PFIZER INC. | 2003-11-27 | — | — | US | disclosed |
| EP-1294724-A1 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS | Pfizer Products Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| US-20020068746-A1 | Pyrrolo[2,3-d]pyrimidine compounds | PFIZER INC. | 2002-06-06 | — | — | US | disclosed |
| WO-2002000661-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2002-01-03 | — | — | WO | disclosed |
| US-5290789-A | Antipsychotically effective compounds | STERLING WINTROP INC. (US) | 1994-03-01 | — | — | US | disclosed |
| US-5286733-A | Treating psychoses | STERLING WINTHROP INC. (US) | 1994-02-15 | — | — | US | disclosed |
| US-4734460-A | STORAGE STABILITY | NIPPON MEKTRON LIMITED, A CORP. OF JAPAN | 1988-03-29 | — | — | US | disclosed |
| US-4558133-A | p-(Pyridinium-vinyl)-N,N-(disubstituted-aniline salts for dyeing paper and their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 1985-12-10 | — | — | US | disclosed |
| EP-0023991-A1 | Styryl dyestuffs, their preparation and their use in dyeing paper in particular | BAYER AG (DE) | 1981-02-18 | — | — | EP | disclosed |
| US-4032596-A | QUATERNARY AMMONIUM SALTS, FREE RADICAL CATALYSTS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1977-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220353-A1 | Pyrrolo[2,3-d]pyrimidine compounds | JAK1, CDK2, JAK3 | ALDH1A1 1719/4885KDM4E 1452/4885RAB9A 1772/4885 |
| US-20020068746-A1 | Pyrrolo[2,3-d]pyrimidine compounds | JAK1, CDK2, JAK3 | ALDH1A1 1719/4885KDM4E 1452/4885RAB9A 1772/4885 |
| US-20070161666-A1 | Pyrrolo[2,3-d]pyrimidine compounds | CDK2, CDK3, JAK3 | ALDH1A1 2505/4885KDM4E 1016/4885RAB9A 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.