Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | VDR | P11473 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL241884 | 0.90 | CA1 (0.52) | GAAVDRCA1CA9CA12 | |
| SCHEMBL1759097 | 0.89 | ALDH1A1 (0.47) | GAAVDRCA1CA9CA12 | |
| SCHEMBL1759342 | 0.89 | ALDH1A1 (0.46) | GAAVDRCA1CA9CA12 | |
| SCHEMBL8856851 | 0.86 | GAA (0.45) | GAAVDRCA1CA9CA12 | |
| Ethylene SCHEMBL3466431 | 0.86 | CA1 (0.50) | GAAVDRCA1CA9CA12 | |
| SCHEMBL483847 | 0.86 | ALDH1A1 (0.50) | GAAVDRCA1CA9CA12 | |
| Ethylene SCHEMBL4379131 | 0.86 | CA1 (0.50) | GAAVDRCA1CA9CA12 | |
| Water SCHEMBL7788572 | 0.86 | CA1 (0.50) | GAAVDRCA1CA9CA12 | |
| SCHEMBL890725 | 0.86 | ALDH1A1 (0.50) | GAAVDRCA1CA9CA12 | |
| SCHEMBL1145153 | 0.84 | ALDH1A1 (0.53) | GAAVDRCA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020009176-A1 | AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF | 田辺三菱製薬株式会社 | 2020-01-09 | — | — | WO | disclosed |
| US-10081600-B2 | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2018-09-25 | — | — | US | disclosed |
| US-20170166531-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION | 2017-06-15 | — | — | US | disclosed |
| US-9517279-B2 | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2016-12-13 | — | — | US | disclosed |
| US-9017645-B2 | Homoglutamic acid derivatives | PIRAMAL IMAGING SA (CH) | 2015-04-28 | — | — | US | disclosed |
| US-20140309424-A1 | DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND THE PROVISION OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-([18F] FLUOROMETHYL) TYROSINE | PIRAMAL IMAGING SA (CH) | 2014-10-16 | — | — | US | disclosed |
| EP-2751087-A1 | DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND THE PROVISION OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-([18F]FLUOROMETHYL)TYROSINE | Piramal Imaging SA (CH) | 2014-07-09 | — | — | EP | disclosed |
| US-20130209362-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130071327-A1 | HOMOGLUTAMIC ACID DERIVATIVES | PIRAMAL IMAGING SA (CH) | 2013-03-21 | — | — | US | disclosed |
| WO-2013001088-A1 | DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND THE PROVISION OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-([18F]FLUOROMETHYL) TYROSINE | PIRAMAL IMAGING SA (CH) | 2013-01-03 | — | — | WO | disclosed |
| US-6041157-A | Environmentally sensitive compositions of matter based on 3H-fluoren-3-ylidenes and process for making same | GOETZ FREDERICK JAMES (US) | 2000-03-21 | — | — | US | disclosed |
| US-5753644-A | Vasopressin antagonist and oxytocin antagonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| US-5622947-A | VASODILATORS, HYPOTENSIVE AGENTS, DIURETICS, PLATELET AGGLUTINATION INHIBITORS; ALSO USED TO PREVENT PREMATURE BIRTH, TREAT DYSMENORRHEA | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-22 | — | — | US | disclosed |
| EP-0514667-B1 | Benzazepin derivatives as vasopressin antagonists | OTSUKA PHARMA CO LTD (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0620003-A1 | VASOPRESSIN ANTAGONIST AND OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |
| US-5244898-A | Vasopressin antagonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0514667-A1 | Benzazepin derivatives as vasopressin antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-25 | — | — | EP | disclosed |
| EP-0133259-A2 | Aminoalkyl-substituted benzene derivatives, process for production thereof, and pharmaceutical composition thereof | KOWA COMPANY, LTD. (JP) | 1985-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10081600-B2 | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof | HTR5A, HTR2C, HTR3A | GAA 2040/4885VDR 476/4885CA1 4347/4885 |
| US-20130209362-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | HTR5A, HTR2C, HTR3A | GAA 2040/4885VDR 476/4885CA1 4347/4885 |
| US-20130071327-A1 | HOMOGLUTAMIC ACID DERIVATIVES | FGB, GGCT, RIMKLA | GAA 61/4885VDR 2981/4885CA1 551/4885 |
| US-20170166531-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | HTR5A, HTR2C, HTR3A | GAA 2040/4885VDR 476/4885CA1 4347/4885 |
| US-20140309424-A1 | DIRECT SYNTHESIS OF 18F-FLUOROMETHOXY COMPOUNDS FOR PET IMAGING AND THE PROVISION OF NEW PRECURSORS FOR DIRECT RADIOSYNTHESIS OF PROTECTED DERIVATIVES OF O-([18F] FLUOROMETHYL) TYROSINE | TH, TYR, FTO | GAA 955/4885VDR 4201/4885CA1 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.