Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593059 | 0.89 | ALDH1A1 (0.39) | LMNAGAATSHRALDH1A1HTT | |
| SCHEMBL17593165 | 0.78 | TRIM24 (0.49) | TRIM24SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL17592909 | 0.73 | CA12 (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17593239 | 0.69 | PHGDH (0.54) | LMNAGAASMN1; SMN2USP2HPGD | |
| SCHEMBL17593148 | 0.68 | ADRB2 (0.44) | TSHRTRIM24SMN1; SMN2POLBMEN1 | |
| SCHEMBL17593076 | 0.66 | NPC1 (0.44) | LMNAGAAHTTSMN1; SMN2KDM4E | |
| SCHEMBL17592956 | 0.65 | CYP2C8 (0.42) | LMNATSHRALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL19332471 | 0.64 | CA1 (0.38) | LMNAALDH1A1HTTKDM4E | |
| SCHEMBL17593251 | 0.63 | L3MBTL1 (0.40) | LMNAALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL17593235 | 0.63 | TP53 (0.52) | LMNASMN1; SMN2KDM4EPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |